Objective      To investigate the clinical application

techniques and efficacy of biomembranes in reconstruction of the sella turcica in transsphenoidal surgery.       Methods      Transsphenoidal surgery was performed in 52 patients with lesions of sellar region. After removal of the lesions

sellar reconstruction with or without diaphragm reconstitution was performed using biomembranes according to different conditions.       Results      Nineteen cases (36.5%) with intraoperative cerebrospinal fluid (CSF) leakage and 6 cases (11.5%) with diaphragm defect but no intraoperative CSF leakage underwent diaphragm reconstitution. All cases underwent sellar reconstruction. The postoperative CSF leakage was found in 4 cases (7.7%)

which was cured by conservative therapy for 5 to 7 d. All patients were followed up for 3 to 48 months. No CSF leakage

bacterial meningitis

tension pneumocephalus or other complication was found.       Conclusion      Reconstruction of the sella turcica using appropriate biomaterials without any adhesive sealants can effectively and safely prevent postoperative and long-term CSF leakage and other complications in patients with traditional transsphenoidal surgery.