Objective       To clarify the plasma metabonomic changes induced by Kansui treatment revealing the toxicity mechanism of Kansui.       Methods       Eighteen SD rats were divided into 3 groups

i.e.

control

low dosage of Kansui group (7.875 g/kg) and high dose group (15.75 g/kg). After 2 weeks

the plasma samples were obtained

and

1

H NMR spectra was performed and analyzed by orthogonal partial least-squares-discriminant analysis (OPLS-DA).       Results       There were some important changes in the plasma metabonomic profiles between Kansui treatment groups and control group. Plasma levels of lactate and creati

ne were increased（

P

0.05）

and those of lipids

3-hydrobutyrate

taurine and glucose were decreased in the 2 Kansui-treated groups（

P

0.05）. Meanwhile

the levels of alanine

O-acetyl-protein and trimethylamine-N-oxide were also elevated （

P

0.05）

and that of unsaturated fatty acid was decreased in high dosage Kansui treatment group （

P

0.05）.       Conclusion       Kansui induces the metabolic disorders of energy metabolism

amino acid and lipid metabolism.