Objective      To establish a chronic retinal degeneration model with Guangxi Bama miniature pig by exposing to continuous intermittent visible light

and to explore the method for examining retinal function in live Guangxi Bama miniature pigs．       Methods      Guangxi Bama miniature pigs aged 3-4 months were exposed to continuous intermittent white light to induce chronic retinal degeneration. Fundus photography

optical cohe-rence tomography (OCT)

full-field electroretinography (fERG) and multifocal electroretinography (mfERG) were used to compare the differences of retinal functions between the normal pigs and light-induced retinal degeneration pigs and to i

dentify optical retinal degeneration in vivo.       Results      As compared to the normal pigs

no significant visible fundus photographic change was found in the light-induced retinal degeneration pigs. Nevertheless

the thickness of retinal internal limiting membrane (ILM) to retinal pigment epithelium (RPE) layer was reduced obviously in OCT (

P

0.05). Amplitudes of dark-adapted combined rod-cone response’s a waves

b waves

and ops waves and light-adapted b waves and P1 waves of fERG also decreased clearly (

P

0.05). Average amplitude density of P1 waves of mfERG significantly lowered (

P

0.05).       Conclusion      Continuous intermittent visible light exposure leads to changes in the structure and function in porcine retinas

producing an appropriate chronic retinal degeneration model.