Depression and anxiety in peri-menopause women with hypothyroidism: a clinical study

宁宁; 郑向红; 封娟毅; 何长武; 王社教; 康岩

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Depression and anxiety in peri-menopause women with hypothyroidism: a clinical study

更新时间：2026-01-09

- Depression and anxiety in peri-menopause women with hypothyroidism: a clinical study
- Journal of Army Medical University Vol. 35, Issue 12, Pages: 1308-1310(2013)
- 作者机构：
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  CLC： R581.2;R711.51;R749.7
- Published：2013
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宁宁,郑向红,封娟毅,何长武,王社教,康岩.围绝经期甲状腺功能减退症患者焦虑及抑郁情绪的临床研究[J].陆军军医大学学报(原第三军医大学学报),2013,35(12):1308-1310.

　Ning Ning,Zheng Xianghong,Feng Juanyi,He Changwu,Wang Shejiao,Kang Yan.Depression and anxiety in peri-menopause women with hypothyroidism: a clinical study[J].J Amry Med Univ (J Third Mil Med Univ),2013,35(12):1308-1310.
宁宁,郑向红,封娟毅,何长武,王社教,康岩.围绝经期甲状腺功能减退症患者焦虑及抑郁情绪的临床研究[J].陆军军医大学学报(原第三军医大学学报),2013,35(12):1308-1310. DOI：

　Ning Ning,Zheng Xianghong,Feng Juanyi,He Changwu,Wang Shejiao,Kang Yan.Depression and anxiety in peri-menopause women with hypothyroidism: a clinical study[J].J Amry Med Univ (J Third Mil Med Univ),2013,35(12):1308-1310. DOI：

摘要

目的以甲状腺功能减退症的围绝经期女性为研究对象，探讨甲状腺激素水平与这类人群焦虑和抑郁情绪的关系。方法采用焦虑自评量表(self-rating anxiety scale，SAS)和抑郁自评量表(self-rating depression scale，SDS)对甲状腺功能正常（对照组，n=33）、亚临床甲状腺功能减退症(亚临床甲减组，n=35)和临床甲状腺功能减退症(临床甲减组，n=78)的围绝经期女性进行评分，评估患者焦虑和抑郁的发生率以及评分与甲状腺激素的相关性。结果临床甲减组SAS标准分较对照组升高（

0.05），亚临床甲减组SAS标准分对照组比较未见明显差异（

0.05）；临床甲减组SDS标准分较其他两组均升高（

0.05），亚临床甲减组SDS标准分较对照组升高（

0.05）。以中国人群常模为界值，各组SAS和SDS评分超过常模的发生率均有显著性差异(

0.05)，其中临床甲减组SAS和SDS评分超过常模的发生率显著高于其余两组(

0.05)，亚临床甲减组显著高于对照组(

0.05)。SAS评分与游离甲状腺素（FT4）和促甲状腺激素(TSH)水平分别呈显著负相关（

=-0.326

0.01）和正相关（

=0.240

0.01）；SDS评分三碘甲状腺原氨酸（FT3）、FT4均呈显著负相关（r=-0.427，

=-0.627

0.01），与TSH呈显著正相关关系（

=0.555

0.01）。结论围绝经期甲状腺功能减退症女性更易出现抑郁和焦虑，该时期患者抑郁和焦虑的程度与甲状腺激素水平相关。

Abstract

Objective To study the relationship of hypothyroidism with depression and anxiety in peri-menopause women. Methods One hundred and thirteen women in peri-menopause period were divided into three groups including a normal control group (n=33)

a subclinical hypothyroidism group (n=

35) and an overt hypothyroidism group (n=78). The anxiety and depression of the subjects were investigated with self-rating anxiety scale (SAS) and self-rating depression scale (SDS). The correlation between thyroid hormones and anxiety/depression was observed. Results The prevalence of anxiety and depression in peri-menopause women with hypothyroidism was higher than that in the control group (

0.05). SAS scores had significantly negative correlation with free thyroxine (FT4) (

=-0.326

0.01) and positive correlation with thyroid stimulating hormone (TSH) (

=0.240

P0.01). SDS scores had significantly negative correlation with free triiodothyronine (FT3) and FT4 (

=-0.427

=-0.627

0.01) and positive correlation with thyroid stimulating hormone (TSH) (

=0.555

0.01). Conclusion The prevalence of anxiety and depression increases in peri-menopause women with hypothyroidism. There is significant correlation between the degree of anxiety/depression and thyroid hormone levels.

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