Geniposide attenuates liver fibrosis in CCl<sub>4</sub>-induced mice

兰天; 曾志; 陈颖华

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Geniposide attenuates liver fibrosis in CCl₄-induced mice

更新时间：2026-01-09

- Geniposide attenuates liver fibrosis in CCl₄-induced mice
- Journal of Army Medical University Vol. 35, Issue 16, Pages: 1752-1755(2013)
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  CLC： R282.71;R285.5;R575.2
- Published：2013
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兰天,曾志,陈颖华.栀子苷改善CCl4引起的小鼠肝纤维化损伤的实验研究[J].陆军军医大学学报(原第三军医大学学报),2013,35(16):1752-1755.

　Lan Tian,Zeng Zhi,Chen Yinghua.Geniposide attenuates liver fibrosis in CCl4-induced mice[J].J Amry Med Univ (J Third Mil Med Univ),2013,35(16):1752-1755.
兰天,曾志,陈颖华.栀子苷改善CCl4引起的小鼠肝纤维化损伤的实验研究[J].陆军军医大学学报(原第三军医大学学报),2013,35(16):1752-1755. DOI：

　Lan Tian,Zeng Zhi,Chen Yinghua.Geniposide attenuates liver fibrosis in CCl4-induced mice[J].J Amry Med Univ (J Third Mil Med Univ),2013,35(16):1752-1755. DOI：

摘要

目的研究栀子苷的抗肝纤维化药理作用。方法雄性C57小鼠采用腹腔注射CCl

构建肝纤维化模型，同时采用栀子苷进行灌胃给药干预。运用HE染色和天狼星红染色检测肝纤维化的变化；生化检测血清丙氨酸转移酶（ALT）和天冬氨酸转移酶（AST）以及肝组织的羟脯氨酸含量。Western blot法检测转化生长因子β1（TGF-β1）及α-SMA的蛋白表达。结果栀子苷显著抑制CCl

诱导的小鼠肝纤维化程度。与纤维化模型组相比，栀子苷治疗组血清ALT、AST水平及肝脏组织中羟脯氨酸水平明显降低（

0.01）。栀子苷显著抑制肝组织中TGF-β1和α-SMA的蛋白表达（

0.01）。结论栀子苷具有显著的改善肝纤维化作用。

Abstract

Objective To investigate the anti-hepatofibrotic effects of geniposide on liver fibrosis. Methods Male C57 mice were induced with 20% CCl

(2 mL/kg) for 6 weeks to induce liver fibrosis

and were treated with intragastrical gavage of 50 mg/kg geniposide for 14 d since the fifth week of CCl

induction. Liver fibrosis of the mice was evaluated by HE staining and Sirius Red staining. Activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST)

and liver content of hydroxyproline were measured with automated biochemistry analyzer. The protein levels of transforming growth factor beta1 (TGF-β1) and α-smooth muscle actin （α-SMA） were detected by Western blot analysi

s. Results Geniposide significantly attenuates the progression of liver fibrosis induced by CCl

. Treatment with geniposide also resulted in significant decreases in the serum levels of ALT and AST

as well as the content of hydroxyproline after CCl

induction（

0.01）. Geniposide significantly reduced the protein expression levels of TGF-β1 and α-SMA in the liver（P0.01）. Conclusion Geniposide exerts anti-fibrotic effects on the liver induced by CCl

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Department of Hepatobiliary Surgery， First Affiliated Hospital（Southwest Hospital）， Army Medical University （Third Military Medical University）

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Geniposide attenuates liver fibrosis in CCl4-induced mice

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Geniposide attenuates liver fibrosis in CCl₄-induced mice