Objective      To investigate the occurrence and outcome of tricuspid regurgitation after transcatheter closure of perimembranous ventricular septal defect (PMVSD).       Methods      From January 2007 to March 2012

332 patients diagnosed as PMVSD and successfully underwent transcatheter interventional therapy in the Southwest Hospital were enrolled

including 182 male patients with an average age of 15.4±12.3 years. Transthoracic echocardiography (TTE) was applied to observe the tri

cuspid regurgitation and its degree before procedure

in 3 d after procedure

and during 1-

3-

6- and 12-month follow-up. The patients were divided into two groups based on the devices applied: a symmetric occluder group and a small-waist occluder group

and the incidence of tricuspid regurgitation in the two groups were compared.       Results      In the 332 patients

181 patients used the symmetric occluders and 151 patients used the small-waist occluders. After procedure

new tricuspid regurgitation or aggregation of primary tricuspid regurgitation were observed in 14 patients (4.2%). There were 8 patients (4.4%) in the symmetric occluder group and 6 patients (4.0%) in the small-waist occluder group

and the difference between the two groups was no statistically significant (

P

=0.84). During the follow-up for (12.1±7.9) months on average

3 patients’ tricuspid regurgitation mitigated. There was no tricuspid regurgitation induced by tricuspid chordae fracture or valve damage.       Conclusion      After transcatheter closure of PMVSD

a small number of patients may develop tricuspid regurgitation

which is unrelated to the types of occluders. The regurgitation generally does not aggravate over time

and the outcome is good.