Relationship of glutathione S-transferase M1 and T1 polymorphisms with the susceptibility of primary angle-closure glaucoma of Chinese Han population in Chongqing

陈瑾; 侯胜平; 高小劲; 胡泊; 李平华

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Relationship of glutathione S-transferase M1 and T1 polymorphisms with the susceptibility of primary angle-closure glaucoma of Chinese Han population in Chongqing

更新时间：2026-01-09

- Relationship of glutathione S-transferase M1 and T1 polymorphisms with the susceptibility of primary angle-closure glaucoma of Chinese Han population in Chongqing
- Journal of Army Medical University Vol. 35, Issue 13, Pages: 1410-1414(2013)
- 作者机构：
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- DOI：
  CLC： R195.4;R394.5;R775.2
- Published：2013
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陈瑾,侯胜平,高小劲,胡泊,李平华.GSTT1和GSTM1基因多态性与重庆地区汉族人群中原发性闭角型青光眼易感性的关系[J].陆军军医大学学报(原第三军医大学学报),2013,35(13):1410-1414.

　Chen Jin,Hou Shengping,Gao Xiaojin,Hu Bo,Li Pinghua.Relationship of glutathione S-transferase M1 and T1 polymorphisms with the susceptibility of primary angle-closure glaucoma of Chinese Han population in Chongqing[J].J Amry Med Univ (J Third Mil Med Univ),2013,35(13):1410-1414.
陈瑾,侯胜平,高小劲,胡泊,李平华.GSTT1和GSTM1基因多态性与重庆地区汉族人群中原发性闭角型青光眼易感性的关系[J].陆军军医大学学报(原第三军医大学学报),2013,35(13):1410-1414. DOI：

　Chen Jin,Hou Shengping,Gao Xiaojin,Hu Bo,Li Pinghua.Relationship of glutathione S-transferase M1 and T1 polymorphisms with the susceptibility of primary angle-closure glaucoma of Chinese Han population in Chongqing[J].J Amry Med Univ (J Third Mil Med Univ),2013,35(13):1410-1414. DOI：

摘要

目的探讨中国汉族人群中谷胱甘肽硫转移酶M1（glutathione S-transferase M1，GSTM1）、谷胱甘肽硫转移酶T1(glutathione S-transferase T1，GSTT1)基因多态性与原发性闭角型青光眼易感性的关系。方法收集211例汉族原发性闭角型青光眼患者（primary angle-closure glaucoma，PACG）以及422例健康志愿者的血液标本（对照组），并根据诊断标准将PACG组分为急性（acute primary angle-closure glaucoma，APACG）和慢性（chronic primary angle-closure glaucoma

CPACG），并采用多重等位基因特异聚合酶链反应（multiplex PCR）技术检测GSTT1和GSTM1基因多态性。结果 GSTT1缺失基因型在PACG组中分布频率为53.1%，在对照组中的分布频率为53.8%，2组间无统计学差异（χ

=0.028 6

P=0.866）；将PACG组分为APACG组和CPACG组后，GSTT1缺失基因型的分布频率分别为46.3%和55.4%，APACG组与对照组相比，无统计学差异（

=0.126 7，

=0.722），CPACG组与对照组相比，差异也无统计学意义（

=0.036 2，

=0.849）。在PACG组中GSTM1的缺失基因型的频率为58.3%，对照组中GSTM1缺失基因型的频率为56.3%，2组间的差异无统计学意义（

=0.206 3

P=0.650）。GSTM1在APACG组以及CPACG组中的分布频率分别为61.1%及56.3%，APACG组与对照组相比，其差异无统计学意义（

=0.027 9，

=0.867）；CPACG组与对照组相比，其差异也无统计学意义（

=0.006 4，

=0.936）。此外，将GSTT1和GSTM1基因型联合进行分析，发现其4种基因型在各个病例组与对照组的比较中都没有统计学差异。结论在重庆地区的中国汉族人群中，未发现GSTT1缺失基因型和GSTM1缺失基因型与原发性闭角型青光眼的易感性相关，联合比较GSTT1和GST

M1基因多态性与原发性闭角型青光眼的易感性，也未发现明显相关性，而且与原发性闭角型青光眼的分类也不相关。

Abstract

Objective To investigate the relationship of genetic polymorphisms of glutathione S-transferase M1 (GSTM1)

and glutathione S-transferase T1 (GSTT1) with the susceptibility of primary angle-closure glaucoma in Chinese Han population. Methods Blood samples were collected from 211 Han patients with primary angle-closure glaucoma (PACG) and 422 health volunteers (control)

and the 211 PACG patients were separated into an acute PACG (APACG) group and a chronic PACG (CPACG) group according to diagnostic criteria. Furthermore

multiple allele-specific polymerase chain reaction (multiplex PCR) was employed to detect the genetic polymorphisms of GSTT1 and GSTM1. Results The distribution frequencies of GSTT1-null genotype were 53.1% and 53.8% in the PACG group and control group

respectively

but no significant difference was found (Chi square=0.028 6

=0.866). Furthermore

the distribution frequencies of GSTT1-null genotype in the APACG group and CPACG group were 46.3% and 55.4%

respectively

which were not significantly different from that of the control group (

Chi

square=0.126 7

=0.722;

Chi

square=0.036 2

=0.849). The distribution frequencies of GSTM1-null genotype were 58.3% and 56.3% in the PACG group and control group

respectively

but no significant difference was found (

Chi

square=0.206 3

=0.650). The distribution frequencies of GSTM1 were 61.1% and 56.3% in the APACG group and CPACG group

respectively

but no significant difference was found as compared with the control group (

Chi

square=0.027 9

=0.867;

Chi

square=0.006 4

=0.936). Moreover

the combined analysis of GSTT1 and GSTM1 genotypes showed that no significant difference was found in comparison of the four genotypes of GSTT1 and GSTM1 between the PACG (APACG and CPACG) group and control group. Conclusi

on In Han population with PACG in Chongqing area of China

no relationship is found between the null genotypes of GSTT1 and GSTM1 and PACG susceptibility

and the correlation of genetic polymorphisms of GSTT1 and GSTM1 with the susceptibility and classification of PACG is not found.

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