Development of self-microemulsifying drug delivery system for honokiol

甘露; 田睿; 郭锋; 王春晖; 左的于; 张良珂

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Development of self-microemulsifying drug delivery system for honokiol

更新时间：2026-01-09

- Development of self-microemulsifying drug delivery system for honokiol
- Journal of Army Medical University Vol. 35, Issue 19, Pages: 2073-2076(2013)
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  CLC： R284.1;R943
- Published：2013
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甘露,田睿,郭锋,王春晖,左的于,张良珂.和厚朴酚自微乳化给药系统的研究[J].陆军军医大学学报(原第三军医大学学报),2013,35(19):2073-2076.

　Gan Lu,Tian Rui,Guo Feng,Wang Chunhui,Zuo Deyu,Zhang Liangke.Development of self-microemulsifying drug delivery system for honokiol[J].J Amry Med Univ (J Third Mil Med Univ),2013,35(19):2073-2076.
甘露,田睿,郭锋,王春晖,左的于,张良珂.和厚朴酚自微乳化给药系统的研究[J].陆军军医大学学报(原第三军医大学学报),2013,35(19):2073-2076. DOI：

　Gan Lu,Tian Rui,Guo Feng,Wang Chunhui,Zuo Deyu,Zhang Liangke.Development of self-microemulsifying drug delivery system for honokiol[J].J Amry Med Univ (J Third Mil Med Univ),2013,35(19):2073-2076. DOI：

摘要

目的筛选并优化了和厚朴酚自微乳化给药系统（honokiol-SMEDDS）的处方。方法利用溶解度，辅料配伍实验及伪三元相图筛选空白处方，以粒径和体外释放评价为指标选取最佳处方。结果优化后的honokiol-SMEDDS处方油相为辛癸酸甘油酯（MCT），表面活性剂为聚氧乙烯氢化蓖麻油（Cremophor RH40），助表面活性剂为二乙二醇单乙基醚（Transcutol P），油相比例20%，表面活性剂与助表面活性剂的比值K

为2，载药量为10%，平均粒径为28 nm。结论成功制备了honokiol-SMEDDS，显著提高了和厚朴酚的溶解度。

Abstract

Objective To screen and optimize the formulation of self-microemulsifying drug delivery system (SMEDDS) for honokiol. Methods The formulation of honokiol-SMEDDS was screened by solubility experiment

compatibility test for excipients and pseudo-ternary phase diagrams. And the best formulation was determined by the particle size and in vitro release evaluation. Results In the best formulation of honokiol-SMEDDS

octyl and decyl glycerate (MCT)

polyoxyethylene hydrogenated castor oil (Cremophor RH40) and diethylene glycol monoethyl ether (Transcutol P) were used as oil phase

surfactant and co-surfactant

respectively. The percentage of oil phase was 20%

of surfactant to cosurfactant was 2

the drug loading was 10%

and the average particle size was 28 nm. C

onclusion The honokiol-SMEDDS is prepared successfully

and the solubility of honokiol is improved significantly.

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