Case-control study on serum lipid levels in patients with and without atrial fibrillation

曹腾飞; 陶晓玲; 张贤锐; 徐艳萍; 周莉; 苏立; 殷跃辉

您当前的位置：

首页 >

文章列表页 >

Case-control study on serum lipid levels in patients with and without atrial fibrillation

更新时间：2026-01-09

- Case-control study on serum lipid levels in patients with and without atrial fibrillation
- Journal of Army Medical University Vol. 35, Issue 15, Pages: 1604-1608(2013)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R181.32;R344;R541.75
- Published：2013
- 稿件说明：
移动端阅览
曹腾飞,陶晓玲,张贤锐,徐艳萍,周莉,苏立,殷跃辉.房颤与非房颤患者血脂水平的病例对照研究[J].陆军军医大学学报(原第三军医大学学报),2013,35(15):1604-1608.

　Cao Tengfei,Tao Xiaoling,Zhang Xianrui,Xu Yanping,Zhou Li,Su Li,Yin Yuehui.Case-control study on serum lipid levels in patients with and without atrial fibrillation[J].J Amry Med Univ (J Third Mil Med Univ),2013,35(15):1604-1608.
曹腾飞,陶晓玲,张贤锐,徐艳萍,周莉,苏立,殷跃辉.房颤与非房颤患者血脂水平的病例对照研究[J].陆军军医大学学报(原第三军医大学学报),2013,35(15):1604-1608. DOI：

　Cao Tengfei,Tao Xiaoling,Zhang Xianrui,Xu Yanping,Zhou Li,Su Li,Yin Yuehui.Case-control study on serum lipid levels in patients with and without atrial fibrillation[J].J Amry Med Univ (J Third Mil Med Univ),2013,35(15):1604-1608. DOI：

摘要

目的研究心房颤动与非心房颤动患者血脂水平的变化并探讨其意义。方法回顾性分析2007年6月至2012年6月于重庆医科大学附属第二医院心内科住院符合纳入标准的598例房颤[包括295例阵发性房颤（paroxysmal atrial fibrillation

PAF）亚组，303例非阵发性房颤（non paroxysmal atrial fibrillation

NPAF）亚组

]

患者的临床资料，对比其一般情况、血图分析、肝功、肾功、血脂、血糖、甲状腺功能、心电图、动态心电图、心脏彩超值等资料，符合纳入标准的596例非房颤患者作为对照，对比分析房颤组及亚组同对照组血脂水平的变化。结果房颤组与对照组在年龄、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、载脂蛋白A1（ApoA1）、载脂蛋白B（ApoB）、白细胞计数（WBC）及中性粒细胞比例、左房内径（LAD）和左室射血分数（EF）有统计学差异（

0.05）。多因素Logistc回归显示，WBC（

=1.119，

0.05）和LAD（

=1.147，

0.05）是房颤的危险因素；TG（

=0.822，

0.05）、HDL（

=0.401，

0.05）、LDL（

=0.736，

0.05）水平与房颤负相关。亚组分析显示HDL（

=0.420，

0.05）、LDL（

=0.695，

0.05）与PAF负相关，而LAD（

=1.078，

0.05）与PAF正相关；在NPAF亚组，HDL（

=0.219，

0.05）、LDL（

=0.638，

0.05）、TG（

=0.676，

0.05）三者一致地与NPAF负相关，是其保护因素，LAD（

=1.247，

0.05）是NAPF的危险因素。结论房颤患者血脂尤其是LDL、HDL水平明显低于非房颤患者，且随着PAF进展为慢性房颤而呈逐渐降低趋势。

Abstract

Objective To investigate the potential association between serum lipids and atrial

fibrillation (AF). Methods Five hundred and ninety-eight patients with AF including 295 patients with paroxysmal AF (PAF) and 303 patients with non-paroxysmal AF (NPAF) were enrolled

and 596 non-AF patients with hypertension and diabetes were served as control. Primary clinical and laboratory data including white blood cell count (WBC)

neutrophilic granulocyte ratio

liver function

blood lipids

blood glucose

renal function

thyroid function

electrocardiograph (ECG)/Holter-ECG and echocardiograph were collected in all patients. The changes of blood lipid levels in the AF group and sub-groups were compared with those of the control group. Results Compared with the control group

there were significant decreases in the levels of triglycerides (TG)

total cholesterol (TC)

high-density lipoprotein (HDL)

low-density lipoprotein (LDL)

apolipoprotein (Apo) A1

ApoB and left ventricular ejection fraction (LVEF) and significant increase in age

WBC count

neutrophilic granulocyte ratio and left atrium diameter (LAD) in the AF group (

0.05). The multivariate stepwise logistic regression analysis showed that WBC and LAD were positively correlated with atrial fibrillation (

=1.119

0.05;

=1.147

0.05)

while TG

HDL and LDL were negatively correlated with atrial fibrillation (OR=0.822

0.05;

=0.401

0.05;

=0.736

0.05). The regression analysis in the subgroups showed that HDL (

=0.420

P0.05) and LDL (

=0.695

0.05) were negatively correlated with PAF

but LAD (

=1.0785

0.05) was positively correlated with PAF. Notably

HDL

LDL and TG (

=0.219

0.05;

=0.638

P0.05;

=0.676

0.05) were negatively correlated with NPAF

and LAD (

=1.247

0.05) was positively correlated with NAPF. Conclusion Blood lipids especially LDL and HDL levels are significantly lower in patients with AF

and are prone to decrease gra

dually with PAF progressing into chronic AF.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Analysis of disease burden of atrial fibrillation and atrial flutter globally and in China and Japan from 1990 to 2021 and future trend prediction

Predictive value of peripheral blood piR-hsa-2700592 for prognosis of atrial fibrillation patients

Predictive value of peripheral blood SNORD55 for prognosis of atrial fibrillation patients

Efficacy and safety of intracardiac echocardiography-guided radiofrequency ablation for atrial fibrillation: a retrospective report of 192 cases

Incidence of atrial fibrillation and its related factors in patients over 40 years old with secondary atrial septal defect before and after interventional closure

Related Author

FANG Lanxi

LIU Guanlin

YANG Yuhang

QI Zhi

DENG Qi

MENG Qiong

YANG Lei

WU Na

Related Institution

School of Public Health， Kunming Medical University， Kunming， Yunnan

First Affiliated Hospital of Kunming Medical University•First Clinical School

School of Public Health， Key Laboratory of Environmental Pollution Monitoring and Disease Control of Ministry of Education， Guizhou Medical University

Department of Epidemiology， Faculty of Military Preventive Medicine， Army Medical University （Third Military Medical University）

Department of Cardiology， First Affiliated Hospital， Army Medical University （Third Military Medical University）

⁰