Objective　　　To compare the incidence of major amputation and mortality in patients with peripheral arterial disease who were given interventional therapy or conservative treatment

and to evaluate the efficacy of interventional therapy and its influencing factors.　　　 Methods　　　We enrolled 251 in-patients with diagnosed peripheral arterial disease from November 2007

to June 2012 in Daping Hospital

Chongqing. Ninety-four patients had a lower extremity arterial balloon dilatation and/or stent implantation

while another 157 patients referred to conservative treatment. All the patients were followed up for mortality and the incidence of cerebral infarction

coronary heart disease and amputation. Ankle-brachial index (ABI)

blood pressure

blood glucose

glycosylated hemoglobin

blood lipids

serum creatinine

and high-sensitivity C-reactive protein (hs-CRP) were measured in 3 d

1

3 and 6 months

and 1

2 years after interventional therapy.　　　 Results　　　The two groups showed significant differences in mortality

the incidence of amputation and cerebral infarction (17.20% vs 7.45%

9.55%

vs

3.19% and 10.83% 

vs 

3.19%

P0.05). The average ABI in the interventional therapy group

which was 0.62±0.25 before operation

showed significant decrease on 3 d

and 1

3

and 6 months after operation (0.88±0.19

0.90±0.11

0.82±0.23 and 0.79±0.20

P

0.01

P

0.05). The results of Logistic regression analysis showed that age was an independent risk factor for the validity of the interventional therapy (

r

=1.678

P

=0.037)

while hs-CRP was an independent risk factor for the rate of restenosis (r=2.096

P

=0.035).　　　 Conclusion　　　Lower limb interventional therapy can effectively improve lower limb blood supply in patients with peripheral arterial disease

and decrease the mortality and the incidence of amputation and cerebral infarction. The elder patients may have worse outcome. A high hs-CRP level indicates a high risk of restenosis.