Objective      To investigate the diagnose accordance rate of liquid-based cytology test (LCT) and tissue biopsy for cervix

and to investigate the clinical application value of LCT combined with tissue biopsy in early screening for cervical epithelial lesions.       Methods      The results of 6 498 cases undergoing cervical LCT inspection during January to December 2011 were retrospectively analyzed. Patients with atypical squamous cells of undetermined significance (ASC-US) or severe than ASC-US were defined as abnormal cytology according to Bethesda system for cytology classifications. Among 377 cases of abnormal cytology

148 cases received biopsy inspection. The cytology and histology results were compared

and the relationship of lesion and ages were analyzed.       Results      In 6 498 cases receiving cervical LCT

the abnormal cytology ratio was 5.80%. Among them

ASC-US were 215 cases (57.03%)

atypical squamous cell cannot exclude high grade squamous intraepithelial lesion (ASC-H) were 36 cases (9.55%)

low grade squamous intraepithelial lesion (LSIL) were 82 cases (21.75%)

high grade squamous intraepithelial lesion (HSIL) were 39 cases (10.34%)

atypical glandular cells of undetermined significance not otherwise specified (AGC-NOS) were 4 cases (1.06%)

and squamous cell carcinoma (SCC) were 1 cases (0.27%). Among the 148 cases of biopsy

cases of inflammation reaction were 39 cases (26.35%)

koilocytotic cells 16 cases (10.81%)

cervical intraepithelial neoplasia (CINⅠ) 32 cases (21.62%)

CINⅡ35 cases (23.65%)

CINⅢ 17 cases (11.49%)

squamous carcinoma 8 cases (5.41%)

and adenocarcinoma 1 cases (0.68%)

which revealing that the cytology results had a high conformity rate with biopsy results. And the onset age of cervical lesions ranged from 30 to 50.       Conclusion      LCT is an important approach of screening for cervical epithelial lesions with its high accuracy. Combination of LCT and tissue biopsy can greatly improve early diagnosis of CIN and carcinoma in cervix.