Objective        To investigate the changes of early cognitive function of laparoscopic cholecystectomy (LC) patients with different general anesthesia.       Methods      Fifty-one ASA Ⅰ-Ⅱ patients of 30-50 years old who un

derwent selective LC were divided into an intravenous anesthesia group

an inhalation anesthesia group and an intravenous inhalational anesthesia group. Mini-mental state examination (MMSE) were examined and compared at the first day before surgery (T

1

)

and the first day (T

2

)

the third day (T

3

) and the seventh day (T

4

) after surgery. Then the incidence and possible risk factors of postoperative cognitive dysfunction (POCD) were evaluated.       Results       (1) At the first day after surgery

POCD occurred in all anesthesia groups

including 4 patients (17.4%) in the intravenous inhalational anesthesia group

2 patients (18.2%) in the inhalation anesthesia group

and 2 patients (11.8%) in the intravenous anesthesia group. No significant difference existed among the 3 groups (P0.05). (2) There was no statistically significant difference in preoperative general situation (including sex

age

body height

hypertension history

diabetes history and surgical history) among the 3 groups (P0.05). But the body weight of patients in the intravenous inhalational anesthesia group showed statistically significant difference as compared with that in the inhalation anesthesia group and intravenous anesthesia group (P0.05). (3) There was no statistically significant difference in perioperative variables (including the dosages of atropine and ephedrine

anesthesia awaking time

extubation time

postoperative hospital stay

and postoperative nausea and vomiting) among the 3 groups (P0.05). (4) Comparison of vital signs at each time point showed that the differences of HR and SpO

2

were not significant among the 3 groups

but the systolic blood pressure (SBP) and diastolic blood pressure (DBP) at T

2

T

3

and T

4

in the inhalation anesthesia group were significantly different from those in the intravenous inhalational anesthesia group and intravenous anesthesia group (P0.05). (5) The number of patients with hypotension during LC had statisticall

y significant difference among the 3 groups

including 2 patients (8.7%) in the intravenous inhalational anesthesia group

6 patients (54.5%) in the inhalation anesthesia group

and 0 patients in the intravenous anesthesia group (P0.05). (6) The results of Logistic regression analysis showed no correlation between postoperative short-term cognitive dysfunction and perioperative variables.       Conclusion        Different kinds of general anesthesia do not increase the incidence of POCD

and have no significant effect on early postoperative cognitive function of patients underwent LC.