Amplitude of low frequency fluctuation based resting-state function MRI in interictal drug refractory epilepsy

李陈渝; 方维东; 王学峰

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Amplitude of low frequency fluctuation based resting-state function MRI in interictal drug refractory epilepsy

更新时间：2026-01-09

- Amplitude of low frequency fluctuation based resting-state function MRI in interictal drug refractory epilepsy
- Journal of Army Medical University Vol. 35, Issue 2, Pages: 149-152(2013)
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  CLC： R445.2;R742.1;R811
- Published：2013
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李陈渝,方维东,王学峰.基于低频振幅算法的难治性癫痫发作间期静息态功能磁共振成像研究[J].陆军军医大学学报(原第三军医大学学报),2013,35(02):149-152.

　Li Chenyu,Fang Weidong,Wang Xuefeng.Amplitude of low frequency fluctuation based resting-state function MRI in interictal drug refractory epilepsy[J].J Amry Med Univ (J Third Mil Med Univ),2013,35(02):149-152.
李陈渝,方维东,王学峰.基于低频振幅算法的难治性癫痫发作间期静息态功能磁共振成像研究[J].陆军军医大学学报(原第三军医大学学报),2013,35(02):149-152. DOI：

　Li Chenyu,Fang Weidong,Wang Xuefeng.Amplitude of low frequency fluctuation based resting-state function MRI in interictal drug refractory epilepsy[J].J Amry Med Univ (J Third Mil Med Univ),2013,35(02):149-152. DOI：

摘要

目的采用功能磁共振成像（functional magnetic resonance imaging

fMRI）探讨难治性癫痫患者发作间期脑功能的改变。方法对难治性癫痫患者和健康对照的功能磁共振数据均采用低频振荡振幅（amplitude of low frequency fluctuation，ALFF）算法分别进行处理，计算并对比难治性癫痫组相比健康对照组ALFF改变的脑区，分析ALFF改变脑区与病程的相关性。结果静息状态下难治性癫痫组与对照组相比ALFF值增强的脑区主要有中脑、桥脑、尾状核、额下回及双侧海马旁回、海马等部位；ALFF值减弱的脑区主要有双侧额叶、右侧颞上回、扣带回后部及相邻的楔前叶，且右侧颞中回的ALFF值与病程呈负相关（r=-0.71，P0.05）。结论难治性癫痫患者发作间期存在广泛的脑功能异常，且与癫痫病程相关。

Abstract

Objective To investigate the interictal brain function in patients with drug refractory epilepsy (DRE) in resting state with blood oxygenation level dependent functional magnetic resonance imaging (BOLD-fMRI). Methods A total of 36 DRE outpatients in our center of epilepsy during March 2010 to June 2011 were subjected in this study. Another health volunteers served as normal control. Data of fMRI in all subjects were calculated and compared using the method of amplitude of low frequency fluctuation (ALFF). The correlation between ALFF and disease duration was analyzed. Results DRE showed significantly strengthened ALFF in midbrain

pons

caudate

inferior frontal gyrus and bilateral parahippocampalgyrus

hippocampus compared with normal controls. Weakened ALFF were found in bilateral frontal lobe

right superior temporal gyrus

anterior cingutate and precuneus. A correlation analysis of ALFF at each voxel in the whole brain against the disease duration in DRE revealed a significantly negative correlation in right middle temporal gyrus (r=-0.71

P0.05). Conclusion The brain function is widespread abnormalities in DRE compared with the normal controls

which may be related with the course of disease.

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