Objective         To investigate the relationship between axonal demyelination after compressed spinal cord injury (CSCI) and expression of myelin basic protein (MBP) and inhibitor of DNA binding 2 (Id2)

and to explore the mechanism of axonal demyelination after CSCI.       Methods        The CSCI model was established with a self-made device. The changes of myelinated nerve fibers in white matter were determined by osmic acid staining at 1

3 and 7 d following CSCI. MBP and Id2 expression levels were observed by double-labeling immunofluorescence and Western blotting.       Results        Axonal demyelination occurred after CSCI and myelin sheath became swelling

degenerative and breakdown with time extending. The expression of MBP was down-regulated after CSCI

which was consistent with the degree of demyelination. Id2 distributed widely in white matter

and its expression increased along with time extending after CSCI.       Conclusion        MBP and Id2 are associated with axonal demyelination

and may contribute to axonal demyelination after CSCI.