Objective      To determine the effect of different parameter setting in enhanced gradient echo T

2

star weighted angiography (ESWAN) sequence on paramagnetic ion (Fe

2+

)’s imaging at different concentrations in vitro.       Methods      A model of FeSO

4

solution at different concentrations was established. The

samples were scanned repeatedly using different numbers of echo time

flip angle (FA)

bandwidth (BW) and field of view (FOV) on the ESWAN sequence for signal changes. Relationship between imaging results and different parameters was analyzed by measuring phase values of interested areas in the images at different layers.       Results      ESWAN displayed slightly high signal of Fe

2+

. When Fe

2+

’s concentration was no more than 0.01 mmol/L

phase value was increased with the increase of concentrations. When Fe

2+

’s concentration was 0.1 mmol/L

artifacts were increased while phase value was decreased. There was no a certain rule in change of phase values under different conditions of number of echo time

FA

BW

and FOV. When Fe

2+

’s concentration was higher than 0.001 mmol/L

the number of echo time was smaller

and the contrast to noise ratio (CNR) was greater (P0.05). When Fe

2+

’s concentration was lesser than 0.01 mmol/L

CNR had no statistically significant difference at different FAs (P0.05). When Fe

2+

’s concentration was higher than 0.001 mmol/L

the CNR value was greater with wider BW (P0.05)

while the CNR difference between different FOVs was not statistically significant (P0.05).       Conclusion      The imaging features are various from different ESWAN sequence parameters

and the number of echo time and bandwidth impact most on the image quality.