Objective      To compare the effects of different dialysis modes

regular hemodialysis (HD)

hemodiafiltration (HDF)

and the combination of hemodialysis and hemoperfusion (HD+HP) on intact parathyroid hormone (iPTH) and microinflammation state of secondary hyperparathyroidism in patients with chronic renal failure.       Methods      A total of 60 patients with chronic renal failure who received maintenance hemodialysis and identified as microinflammation in our hospital during November 2011 to January 2012 were enrolled in this study. They were randomly assigned to above 3 treatments respectively for 3 months

with 20 patients in each group. Their blood samples were collected before and at the end of treatment for serum levels of IL-6

TNF-α

intact parathyroid hormone (iPTH) and C-reactive protein (CRP)．       Results      The serum level of CRP was reduced significantly through dialysis in HD+HP group

while no significance was found in the HD and HDF groups. The serum levels of iPTH

IL-6 and TNF-α were reduced significantly through dialysis in HD+HP and HDF groups

while no significance was found in the HD group. The clearance of HD+HP group was higher than that of HDF group (P0.05). The symptoms of osteodynia

myasthenia

skin itch

and angina pectoris were improved in HD+HP and HDF groups

much better than in HD group (P0.05). Correlation analysis showed that serum CRP level was significantly positively correlated with IL-6 (r=0.554

P0.01) and TNF-α (r=0.572，P0.01)

and serum iPTH was significantly positively correlated with CRP (r=0.541，P0.01)

IL-6 (r=0.533，P0.01) and TNF-α (r=0.516

P0.01) .       Conclusion      HD+HP can efficiently eliminate the serum levels of IL-6

TNF-α

iPTH and CRP in secondary hyperparathyroidism patients with chronic renal failure

better than HDF and HD. and thus improve the microinflammation state and clinical manifestation.