Correlation between serum levels of hyaluronic acid, laminin, procollagen  Ⅲ  and collagen Ⅳ and pathological stage of hepatic fibrosis in chronic hepatitis B patients with low duplication of HBV-DNA

张立婷; 赵荣荣; 陈红; 李俊峰

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Correlation between serum levels of hyaluronic acid, laminin, procollagen Ⅲ and collagen Ⅳ and pathological stage of hepatic fibrosis in chronic hepatitis B patients with low duplication of HBV-DNA

更新时间：2026-01-09

- Correlation between serum levels of hyaluronic acid, laminin, procollagen Ⅲ and collagen Ⅳ and pathological stage of hepatic fibrosis in chronic hepatitis B patients with low duplication of HBV-DNA
- Journal of Army Medical University Vol. 34, Issue 17, Pages: 1783-1785(2012)
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  CLC： R512.62;R446.112;R446.8
- Published：2012
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张立婷,赵荣荣,陈红,李俊峰.HBV-DNA低复制慢性乙肝患者血清HA、LN、PcⅢ、CⅣ水平与肝纤维化病理分期相关性分析[J].陆军军医大学学报(原第三军医大学学报),2012,34(17):1783-1785.

　Zhang Liting,Zhao Rongrong,Chen Hong,Li Junfeng.Correlation between serum levels of hyaluronic acid, laminin, procollagen Ⅲ and collagen Ⅳ and pathological stage of hepatic fibrosis in chronic hepatitis B patients with low duplication of HBV-DNA[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(17):1783-1785.
张立婷,赵荣荣,陈红,李俊峰.HBV-DNA低复制慢性乙肝患者血清HA、LN、PcⅢ、CⅣ水平与肝纤维化病理分期相关性分析[J].陆军军医大学学报(原第三军医大学学报),2012,34(17):1783-1785. DOI：

　Zhang Liting,Zhao Rongrong,Chen Hong,Li Junfeng.Correlation between serum levels of hyaluronic acid, laminin, procollagen Ⅲ and collagen Ⅳ and pathological stage of hepatic fibrosis in chronic hepatitis B patients with low duplication of HBV-DNA[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(17):1783-1785. DOI：

摘要

目的研究HBV-DNA低复制、肝功能基本正常或轻微异常的慢性乙肝患者（chronic hepatitis B，CHB）肝纤维化血清指标与肝组织纤维化程度之间的关系。方法选择84例HBV-DNA低复制、肝功基本正常或轻微异常的CHB患者，采用双抗体夹心酶联免疫法检测血清透明质酸(HA)、层粘连蛋白(LN)、Ⅲ型胶原(PcⅢ)、Ⅳ型胶原(CⅣ)水平，并与其肝组织病理分期进行对比研究。结果不同年龄段的HBV-DNA低复制、肝功基本正常或轻微异常的CHB患者其HA、LN、PcⅢ、CⅣ水平均具有显著性差异（P0.01），血清HA、PcⅢ和CⅣ水平随着肝内纤维化程度的加重而递增，并与肝纤维化程度呈正相关，而LN水平在肝纤维化各期无明显差异，与肝纤维化程度无明显相关性（P0.05）。结论对于不同年龄段的HBV-DNA低复制、肝功基本正常或轻微异常的CHB患者，血清肝纤维化指标可作为反映此类患者肝纤维化程度的参考指标，并对该类患者治疗时期的选择具有一定的指导意义。

Abstract

Objective To investigate the correlation between the serum markers and the pathological stage of hepatic fibrosis in chronic hepatitis B patients with low duplication of HBV-DNA and normal or mildly abnormal hepatic function. Methods Eighty-four hepatitis B patients with low duplication of HBV-DNA and normal or mildly abnormal hepatic function were enrolled and divided into a young group (age 45 years

n=58) and an old group (age≥45 years

n=26). The serum levels of hyaluron

ic acid (HA)

laminin (LN)

procollagen III (Pc III) and collagen IV (C IV) were measured by enzyme-linked immunosorbent assay

and meanwhile liver biopsy was performed to examine the pathological stage (S

-S

) of hepatic fibrosis. Results The serum levels of HA

Pc III and C IV were significantly higher in the old group than in the young group (P0.01). The serum levels of HA

Pc III and C IV increased along with the aggravation of hepatic fibrosis

and they were positively correlated with the pathological stage of hepatic fibrosis (r=0.618

0.575 and 0.492

respectively; P0.01). The serum level of LN was not correlated with the degree of hepatic fibrosis (P0.05). Conclusion In hepatitis B patients with low duplication of HBV-DNA and normal or mildly subnormal hepatic function

the serum levels of HA

Pc III and C IV can be used as markers for predicting the pathological stage of hepatic fibrosis.

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