Clinical value of TTF-1 and SPA expression in predicting EGFR mutations in lung adenocarcinoma

刘瑞青; 申淑景; 马杰; 刘杰; 李醒亚

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Clinical value of TTF-1 and SPA expression in predicting EGFR mutations in lung adenocarcinoma

更新时间：2026-01-09

- Clinical value of TTF-1 and SPA expression in predicting EGFR mutations in lung adenocarcinoma
- Journal of Army Medical University Vol. 34, Issue 22, Pages: 2314-2317(2012)
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  CLC： R394.1;R446.8;R734.2
- Published：2012
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刘瑞青,申淑景,马杰,刘杰,李醒亚.肺腺癌组织中TTF-1和SPA的表达对EGFR突变的临床预测价值[J].陆军军医大学学报(原第三军医大学学报),2012,34(22):2314-2317.

　Liu Ruiqing,Shen Shujing,Ma Jie,Liu Jie,Li Xingya.Clinical value of TTF-1 and SPA expression in predicting EGFR mutations in lung adenocarcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(22):2314-2317.
刘瑞青,申淑景,马杰,刘杰,李醒亚.肺腺癌组织中TTF-1和SPA的表达对EGFR突变的临床预测价值[J].陆军军医大学学报(原第三军医大学学报),2012,34(22):2314-2317. DOI：

　Liu Ruiqing,Shen Shujing,Ma Jie,Liu Jie,Li Xingya.Clinical value of TTF-1 and SPA expression in predicting EGFR mutations in lung adenocarcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(22):2314-2317. DOI：

摘要

目的探讨肺腺癌组织中甲状腺转录因子（thyroid transcription factor-1

TTF-1）和表面活性物质A（surfactant protein-A

SPA）的表达对表皮生长因子受体（epidermal growth factor receptor，EGFR）突变状态的临床预测价值。方法收集2005年1月至2011年11月在河南省肿瘤医院行EGFR突变检测的肺腺癌患者235例，其中能找到石蜡组织共120例，采用免疫组织化学方法检测组织中的TTF-1和SPA的表达。分析TTF-1和SPA 的表达与EGFR突变状态、临床特征的关系。结果入组患者的EGFR突变率为43.8%（103/235）；其中的120例患者中有50例发生EGFR突变； TTF-1阳性表达多见于女性（P=0.029）、不吸烟（P=0.025）和Ⅰ～Ⅱ期（P=0.044）患者；EGFR突变多发生于TTF-1或者SPA（P=0.043）阳性表达患者，TTF-1阴性表达时EGFR很少发生突变（P=0.004），TTF-1对EGFR突变状态的阴性预测价值高达92.6%； TTF-1表达与SPA表达呈显著正相关（r=0.380

P=0.005）。结论肺腺癌组织中TTF-1和SPA的表达情况能预测EGFR突变状态，TTF-1或者SPA 阴性表达患者很少发生EGFR突变；TTF-1和SPA的表达具有很好的相关性。

Abstract

Objective To explore the clinical value of the expression of thyroid transcription factor-1 (TTF-1) and surfactant protein-A (SPA) in predicting epidermal growth factor receptor (EGFR) mutations in lung adenocarcinoma. Methods A total of 235 patients with lung adenocarcinoma who were examined for EGFR mutations from January 2005 to November 2011 in Henan Province Tumor Hospital were enrolled

and 120 patients had paraffin-embedded lung tissue specimens. The expression of TTF-1 and SPA was detected by immunohistochemistry. The correlation of the TTF-1 and SPA expression with EGFR mutations and clinical features in lung adenocarcinoma were analyzed. Results There were 103 patients with EGFR mutations in exon 19 or 21 (43.8%

103/235)

and 50 patients with EGFR mutations in the 120 patients. TTF-1 expression was significantly associated with female (P=0.029)

non-smokers (P=0.025) and stage Ⅰ-Ⅱ lung adenocarcinoma (P=0.044). EGFR mutation was commonly detected in the patients with TTF-1 or SPA (P=0.043) positive expression

but was rarely found in the patients with TTF-1 negative expression (P=0.004). The negative predictive value of TTF-1 expression for EGFR mutations was 92.6%. TTF-1 expression was correlated with SPA expression (r=0.380

P=0.005). Conclusion The expression of TTF-1 and SPA in lung adenocarcinoma helps predict EGFR mutations

and the patients with negative expression of TTF-1 and SPA have few EGFR mutations. The expression of TTF-1 is closely correlated with SPA expression.

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