Objective       To investigate the correlation between gene polymorphism of human platelet antigens (HPA1-6

15) in Guizhou Province and acute myocardial infarction (AMI).       Methods       A total of 86 newly diagnosed AMI patients with a mean age of 61.05±10.27 years

who were in line with 1979 WHO diagnostic criteria

identified with coronary angiography and hospitalized in our affiliated hospital form April 2010 to October 2010 were enrolled in this study. Another 85 health individuals with a mean age of 60.74±6.88 and without any cardiovascular disease and thrombosis served as control. Sequence-specific primer-polymerase chain reaction (SSP-PCR) was employed to amplify the target gene

and genotype HPA gene. Regression analysis was used to analyze whether its polymorphism was the risk factors of AMI.       Results        Compared with the control group

HPA2 polymorphism in AMI group had significantly difference (P0.01

OR=26.36

95%CI=8.317 to 83.549)

while HPA1

3-6

15 gene polymorphism had no difference (P0.05). Multiple regression analysis showed there was no significant difference in HPA1ab genotype between AMI group and control (P0.05)

but HPA1ab genotype had 4.3-fold higher risk in the incidence of AMI than HPA1aa homozygote. There was statistically significant difference in HPA2aa genotype and HPA2b allele （P0.01，OR=0.148，95%CI=0.071 to 0.307; P0.01，OR=6.221，95%CI=3.201 to 12.091）.       Conclusion        HPA1ab heterozygous carriers have a higher risk of AMI compared with those with HPA1aa homozygote. HPA2aa homozygote may be a protective factor for AMI onset

while HPA2b allele might be an independent genetic risk factor for incidence of AMI.