Preliminary observation on the effect of Gamma Knife treatment for 20 glioma patients with <sup>1</sup>H-MRS guidance

姚一搏; 许民辉; 徐伦山; 耿明英; 谭勇; 李飞鹏; 沈光建

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Preliminary observation on the effect of Gamma Knife treatment for 20 glioma patients with ¹H-MRS guidance

更新时间：2026-01-09

- Preliminary observation on the effect of Gamma Knife treatment for 20 glioma patients with ¹H-MRS guidance
- Journal of Army Medical University Vol. 34, Issue 18, Pages: 1881-1883(2012)
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  CLC： R445.2;R817.5;R739.41
- Published：2012
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姚一搏,许民辉,徐伦山,耿明英,谭勇,李飞鹏,沈光建.1H-MRS引导辅助伽玛刀治疗20例脑胶质瘤的初步观察[J].陆军军医大学学报(原第三军医大学学报),2012,34(18):1881-1883.

　Yao Yibo,Xu Minhui,Xu Lunshan,Geng Mingying,Tan Yong,Li Feipeng,Shen Guangjian.Preliminary observation on the effect of Gamma Knife treatment for 20 glioma patients with 1H-MRS guidance[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(18):1881-1883.
姚一搏,许民辉,徐伦山,耿明英,谭勇,李飞鹏,沈光建.1H-MRS引导辅助伽玛刀治疗20例脑胶质瘤的初步观察[J].陆军军医大学学报(原第三军医大学学报),2012,34(18):1881-1883. DOI：

　Yao Yibo,Xu Minhui,Xu Lunshan,Geng Mingying,Tan Yong,Li Feipeng,Shen Guangjian.Preliminary observation on the effect of Gamma Knife treatment for 20 glioma patients with 1H-MRS guidance[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(18):1881-1883. DOI：

摘要

目的调查

H核磁共振波谱（

H-MRS）引导辅助伽玛刀治疗脑胶质瘤的效果。方法选择有明确病理诊断的脑胶质瘤20例，分为常规核磁共振（MRI）定位组和MRI结合核磁共振波谱（MRS）定位组，各10例。常规MRI定位组以肿瘤性增强病灶及周围短T

、长T

区为靶灶范围；MRI+MRS定位组则以肿瘤性增强病灶及周围短T

、长T

区间Cho:NAA指数（CNI）≥1.6者为靶灶范围。以伽玛刀治疗后12个月为终未观察期，统计分析两组治疗结果。结果治疗有效者13例（65%），包括常规MRI定位组6例，MRI+MRS定位组7例。10例（50%）患者发生脑水肿，包括常规MRI定位组8例，MRI+MRS定位组2例。统计分析示MRI+MRS定位组靶灶直径、脑水肿发生例数、脑水肿范围较常规MRI定位组明显下降（P0.05）。结论伽玛刀治疗加入MRS因素有助于对脑胶质瘤甄别，减少因盲目扩大治疗范围带来的并发症。

Abstract

Objective To investigate the effect of Gamma Knife treatment for glioma with

H-magnetic resonance spectroscopy (MRS) guidance. Method Twenty patients with glioma confirmed by pathological diagnosis were selected and divided into a conventional MRI positioning group and a MRI+MRS positioning group (n=10). The target area of the conventional MRI positioning group was defined as the tumorous-enhanced focus plus the surrounding short T

and long T

area

and that of the MRI+MRS positioning group was defi

ned as the tumorous-enhanced focus plus the Cho: NAA index (CNI)≥1.6 area in the surrounding short T

and long T

area. The differences of the treatment outcomes were statistically analyzed at 12 months after the Gamma Knife treatment. Results Thirteen (65%) of the 20 patients showed effective outcome

including 6 patients from the conventional MRI positioning group and 7 patients from the MRI+MRS positioning group. Brain edema was observed in 10 patients (50%)

including 8 patents from the conventional MRI positioning group and 2 patients from the MRI+MRS positioning group. The average maximum diameter of target area

the number of patients with brain edema and the range of brain edema decreased significantly in the MRI+MRS positioning group as compared with the conventional MRI positioning group (P0.05). Conclusion Gamma Knife treatment with

H-MRS guidance helps distinguish glioma

and can reduce the complications from the blind expansion of treatment area.

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Related Author

姚一搏

许民辉

耿明英

谭勇

李飞鹏

沈光建

WANG Hanwei

ZENG Linlan

Related Institution

Department of Radiology， Chongqing Clinical Research Centre of Imaging and Nuclear Medicine, Faculty of Biomedical Engineering and Imaging Medicine， Army Medical University （Third Military Medical University）

Department of Neurosurgery， Army Medical Center of PLA/Daping Hospital of Third Military Medical University， Chongqing, Faculty of Biomedical Engineering and Imaging Medicine， Army Medical University （Third Military Medical University）

Department of Digital Medicine, Faculty of Biomedical Engineering and Imaging Medicine， Army Medical University （Third Military Medical University）

School of Medicine， Chongqing University

Institute of Pathology

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Preliminary observation on the effect of Gamma Knife treatment for 20 glioma patients with 1H-MRS guidance

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摘要

Abstract

关键词

Keywords

references

Preliminary observation on the effect of Gamma Knife treatment for 20 glioma patients with ¹H-MRS guidance