Expression and clinical significance of XIAP and c-jun in human lung cancer tissues

刘晓丽; 马礼鸿; 王全义; 王凯

您当前的位置：

首页 >

文章列表页 >

Expression and clinical significance of XIAP and c-jun in human lung cancer tissues

更新时间：2026-01-09

- Expression and clinical significance of XIAP and c-jun in human lung cancer tissues
- Journal of Army Medical University Vol. 34, Issue 23, Pages: 2408-2410(2012)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R730.23;R734.2
- Published：2012
- 稿件说明：
移动端阅览
刘晓丽,马礼鸿,王全义,王凯.XIAP、c-jun在肺癌组织中的表达及其意义[J].陆军军医大学学报(原第三军医大学学报),2012,34(23):2408-2410.

　Liu Xiaoli,Ma Lihong,Wang Quanyi,Wang Kai.Expression and clinical significance of XIAP and c-jun in human lung cancer tissues[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(23):2408-2410.
刘晓丽,马礼鸿,王全义,王凯.XIAP、c-jun在肺癌组织中的表达及其意义[J].陆军军医大学学报(原第三军医大学学报),2012,34(23):2408-2410. DOI：

　Liu Xiaoli,Ma Lihong,Wang Quanyi,Wang Kai.Expression and clinical significance of XIAP and c-jun in human lung cancer tissues[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(23):2408-2410. DOI：

摘要

目的探讨XIAP及c-jun在原发性肺癌组织中的表达水平及其临床意义。方法选用组织芯片应用免疫组化S-P法检测XIAP、c-jun蛋白在正常肺组织、肺良性病变、肺癌旁组织和原发性肺癌组织中的表达。结果 XIAP、c-jun 在肺癌组织中的阳性表达率均明显升高，恶性组显著高于正常组、良性组和癌旁组（P0.05），XIAP、c-jun在肺癌临床晚期（Ⅲ期和Ⅳ期）组的阳性表达水平（MOD值）均明显高于临床早期（Ⅰ期和Ⅱ期）组（P0.05），XIAP、c-jun的阳性表达水平在有淋巴结转移组均高于无淋巴结转移组（P0.05），XIAP与c-jun在肺癌组织中阳性表达呈正相关（r=0.232，P0.05），术后生存期小于1年患者的XIAP、c-jun阳性表达率均明显高于生存期超过1年患者（P0.05）。XIAP、c-jun的MOD值与患者性别、年龄、肿块直径和组织学类型均无关（P0.05）。结论 XIAP、c-jun蛋白阳性水平的高表达提示患者预后较差，联合检测XIAP、c-jun蛋白阳性表达水平可作为临床诊断及患者预后预测的参考指标。

Abstract

Objective To investigate the expression levels and clinical significance of X-linked inhibitor of apoptosis protein (XIAP) and c-jun in primary lung cancer tissues. Methods Immunohistochemical SP method was used to detect the expression levels of XIAP and c-jun in normal lung tissues

lung benign lesions

adjacent tissues of lung cancer and primary lung cancer tissues. Results The positive expression rates of XIAP and c-jun in the primary lung cancer tissues were significantly higher than those in the normal lung tissues

lung benign lesions and adjacent tissues of lung cancer (P0.05). The positive expression levels (MOD value) of XIAP and c-jun in advanced lung cancer tissues (Stage Ⅲ and Ⅳ) were significantly higher than those in the early-stage lung cancer tissues (Stage Ⅰ and Ⅱ) (P0.05). The positive expression levels of XIAP and c-jun in the lung cancer tissues with lymph node metastasis were significantly higher than those in the lung cancer tissues without lymph node metastasis (P0.05). The positive expression levels (MOD value) of XIAP and c-jun were positively correlated in the lung cancer tissues (r=0.232，P0.05). The positive expression levels of XIAP and c-jun in the patients with postoperative survival time less than 1 year were significantly higher than those in the patients with postoperative survival time more than 1 year (P0.05). The positive expression levels (MOD value) of XIAP and c-jun were not correlated with patients’ age

sex

tumor diameter or histopathological type (P0.05). Conclusion High expression of XIAP and c-jun indicates poor prognosis of patients with lung cancer. XIAP and c-jun expression levels can be used as reference indices for clinical diagnosis and prognosis prediction in patients with lung cancer.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Expression of P504s and claudin-4 in prostate cancer and prognostic value of their combined detection

Expression and clinicopathological significance of claudin 3 and 4 in esophageal squamous carcinoma and precancerous lesion

Expressions, clinicopathological features and prognostic significance of HIF-1α, JNK1, P-gp, MRP1 and LRP proteins in human gastric carcinoma

A novel estrogen receptor expression stratification (low/moderate/high) based on Chinese population provides more accurate prognosis prediction for HR⁺/HER2^- early breast cancer patients

Immunosuppressive microenvironment of TGIF1-overexpressing gastric cancers and its clinical significance

Related Author

毕罡

毛成毅

江军

张尧

张军

龙吟

徐胤

王璞

Related Institution

Department of Breast and Thyroid Surgery， First Affiliated Hospital， Army Medical University （Third Military Medical University）

Department of Gastroenterology， Chongqing Hechuan District People’s Hospital

School of Medicine， Chongqing University

Chongqing Key Laboratory of Precision Prevention and Treatment for Digestive System Tumors， Department of Gastroenterology， Army Medical Center of PLA/Daping Hospital of Third Military Medical University

Department of Hematology, the First Hospital of Lanzhou University

⁰