Objective      To investigate the efficiency of multimode CT to guide intra-arterial thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA).       Methods      From June 2010 to June 2012

the patients within 6 h after stroke who visited our department were recruited

and evaluated by multimode CT scanning. There were 32 chosen patients eligible to receive intra-arterial thrombolytic therapy with rt-PA. They were 22 males and 10 females

with an age of 39 to 73 (mean 64). They were divided into 2 groups

within 3 h group and 3 to 6 h group according to the time after onset of ischemic stroke. Their NIH stroke scale (NIHSS)

modified Rankin score (mRS)

and Barthel indexes were recorded before and after intra-arterial thrombolytic therapy.       Results      After rt-PA treatment

26 of 32 (81.3%) patients obtained sound outcome of thrombolytic therapy. Favorable outcome was obtained in 71.9% patients (23/32). Sixteen patients (50%) had recanalization in the occluded arteries after rt-PA treatment. There was l patient (3.1％) having symptomatic intracranial hemorrhage (ICH) in the cohort of patients. NIHSS

mRS and BI score was improved after thrombolytic therapy. There was no significant difference between 2 groups in safety of thrombolytic therapy.       Conclusion      Multimode CT evaluation in the rt-PA therapy is an useful tool to select eligible patients after acute ischemic stroke for intra-arterial thrombolytic therapy.