Objective        To analyze th

e correlation between coagulation parameters and clinicopathological characteristics in patients with breast cancer.        Methods       A total of 539 cases of patients with breast cancer  who admitted in our center from March 2010 to May 2011 were enrolled in this study. They were all female

with a median age of 46. Another 102 age-matched patients with benign breast disease who admitted at the same time served as control. The routine blood function test was performed in them to detect coagulation parameters including prothrombin time (PT)

percentage activity (PT%)

prothrombin time international normalized ratio (PT INR)

activated partial thromboplastin time (APTT)

thrombin time(TT)

fibrinogen (Fib) and D-dimer (D-D). The correlation between coagulation parameters and clinicopathological characteristics in patients with breast cancer was analyzed.        Results       Those patients with breast cancer had shorter APTT (24.28±3.21 vs 25.89±3.76 s

P0.05) and lower APTT Ratio (0.88±0.12 vs 0.94±0.14，P0.05)

increased Fib (2.82±0.67 vs 2.45±0.46 g/L

P0.05)

D-D levels (122±144 vs 97±57 ng/ml

P0.05)

and longer TT (16.88±1.24 vs 16.61±1.28 s

P0.05) when compared with benign breast disease. A higher Fib level was found in patients with T

3

/T

4

tumor than with T

1

/T

2

tumor (P0.05)

in those with lymph node metastasis than those without (P0.05)

as well as in patients with tumor local recurrence or metastasis than those in grade Ⅰ to Ⅲ (P0.05). While there was no difference in coagulation parameters in breast cancer patients positive or negative to estrogen receptor      (ER) and progesterone receptor (PR)

and those with mild expression of human epidermal growth factor receptor 2 (HER-2) and with strong expression.       Conclusion        Breast cancer patients are prone to be in hypercoagulable state. A higher level of Fib is found in patients with a T

3

/T

4

tumor

lymph node metastasis and tumor local recurrence or metastasis.