The treatment of patients with refractory epilepsy has always been challenging. Despite the availability of multiple antiepileptic drugs

approximately 20%-30% of patients continue to have seizures

and many are not candidates for epilepsy surgery. Currently available treatment options for these unfortunate patients are limited. Brain electric stimulation provides a nondestructive treatment for these patients. Studies of electrical stimulation of the brain in epilepsy treatment begin with the research on cerebellar stimulation. Until now

the potential targets have increased over the years

including cortex

cranial nerve and multiple brain nuclei. With the development of therapeutic brain devices for epilepsy

it is convinced that the brain electric stimulation will become more widely applied in treatment of epilepsy. This overview

combining with literatures and our experiences

briefly summarizes the application of brain electric stimulation in the treatment of epilepsy.