Expression of fatty acid amide hydrolase in colorectal cancer and its clinical significance

邓佳; 谢赣丰; 舒秋霞; 王宁; 梁后杰

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Expression of fatty acid amide hydrolase in colorectal cancer and its clinical significance

更新时间：2026-01-09

- Expression of fatty acid amide hydrolase in colorectal cancer and its clinical significance
- Journal of Army Medical University Vol. 34, Issue 9, Pages: 899-901(2012)
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  CLC： R341.5;R730.23;R735.35
- Published：2012
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邓佳,谢赣丰,舒秋霞,王宁,梁后杰.脂肪酰胺水解酶在结直肠癌中的表达及临床意义[J].陆军军医大学学报(原第三军医大学学报),2012,34(09):899-901.

　Deng Jia,Xie Ganfeng,Shu Qiuxia,Wang Ning,Liang Houjie.Expression of fatty acid amide hydrolase in colorectal cancer and its clinical significance[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(09):899-901.
邓佳,谢赣丰,舒秋霞,王宁,梁后杰.脂肪酰胺水解酶在结直肠癌中的表达及临床意义[J].陆军军医大学学报(原第三军医大学学报),2012,34(09):899-901. DOI：

　Deng Jia,Xie Ganfeng,Shu Qiuxia,Wang Ning,Liang Houjie.Expression of fatty acid amide hydrolase in colorectal cancer and its clinical significance[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(09):899-901. DOI：

摘要

目的检测脂肪酰胺水解酶（fatty acid amide hydrolase，FAAH）在结直肠癌及正常肠黏膜中的表达，探讨其临床意义。方法应用Western blot和组织芯片技术结合免疫组化法检测结直肠癌组织以及对应正常肠黏膜中FAAH蛋白的表达。结果 FAAH在结直肠癌组织中的表达低于正常肠黏膜，169例结直肠癌组织中FAAH的阳性表达率显著低于正常肠黏膜（56.8% vs 97.4%，P0.01），并与肿瘤的分化程度密切相关（P0.01）。结论 FAAH在结直肠癌组织中低表达，在正常肠黏膜中高表达，在结直肠癌的恶性增殖中发挥着重要作用。

Abstract

Objective To investigate the expression of fatty acid amide hydrolase (FAAH) in colorectal cancer and normal intestinal mucosa

and to explore the clinical significance of FAAH. Methods Western blotting and immunohistochemical staining were applied for the detection of FAAH expression in 169 cases of colorectal cancer tissues and 38 cases of normal intestinal mucosae. Results The expression level of FAAH in the colorectal cancer tissues was lower than that in the normal intestinal mucosae. The positive expression rate of FAAH in the colorectal cancer tissues was significantly lower than that in the normal intestinal mucosae (56.8% vs 97.4%

P0.01). FAAH expression was significantly correlated with tumor differentiation degree (P0.01). Conclusion FAAH

which is mildly expressed in colorectal cancer tissue but highly expressed in normal intestinal mucosa

plays an important role in the malignant proliferation of colorectal cancer.

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