Objective      To compare the efficacy of olanzapine-fluoxetine combination (OFC) with duloxetine in treatment of persistent somatoform pain disorder.       Methods      A  case-control study was performed. Thirty-five patients were treated with OFC (OFC group)

and other thirty-three patients were treated with duloxetine (duloxetine group). All the patients were treated for 12 weeks (acute phase). The indicators including scores of pain intensity-Numerical Rating Scale (PI-NRS)

Clinical Global Impression-Severity scale (CGI-S)

Clinical Global Impression-efficacy index (CGI-EI) and Hamilton Depression Rating Scale for Depression (HAMD-24) were used for evaluation before treatment and at the 1st

2nd

4th

8th and 12th weekends after treatment.       Results      At all time points after treatment

PI-NRS scores in the OFC group were significantly lower than those in the duloxetine group (P0.05

P0.01)

while CGI-EI scores were significantly higher in the OFC group than in the duloxetine group (P0.01). There were no significant differences in HAMD-24 scores at different time points after treatment between the two groups (P0.05).       Conclusion      The efficacy of OFC is better than that of duloxetine alone in the treatment of somatoform pain disorder at acute phase.