Apoptosis and necroptosis in developing of mouse nephron

邵姝元; 刘玉玲; 郭敏; 李晓明

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Apoptosis and necroptosis in developing of mouse nephron

更新时间：2026-01-09

- Apoptosis and necroptosis in developing of mouse nephron
- Journal of Army Medical University Vol. 34, Issue 9, Pages: 874-878(2012)
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  CLC： R322.61;R329.25
- Published：2012
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邵姝元,刘玉玲,郭敏,李晓明.小鼠肾单位发育过程中的经典凋亡和坏死性凋亡[J].陆军军医大学学报(原第三军医大学学报),2012,34(09):874-878.

　Shao Shuyuan,Liu Yuling,Guo Min,Li Xiaoming.Apoptosis and necroptosis in developing of mouse nephron[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(09):874-878.
邵姝元,刘玉玲,郭敏,李晓明.小鼠肾单位发育过程中的经典凋亡和坏死性凋亡[J].陆军军医大学学报(原第三军医大学学报),2012,34(09):874-878. DOI：

　Shao Shuyuan,Liu Yuling,Guo Min,Li Xiaoming.Apoptosis and necroptosis in developing of mouse nephron[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(09):874-878. DOI：

摘要

目的观察小鼠肾单位发育过程中的程序性细胞死亡现象。方法应用光镜、透射电镜、原位缺口末端标记法及免疫组织化学技术观察胚龄12、14、16、18 d 胎鼠肾单位发育过程中的细胞凋亡。结果小鼠肾单位发育过程中的程序性细胞死亡主要有经典凋亡、坏死性凋亡和副凋亡3种方式。随着小鼠胚龄增加，凋亡指数逐渐升高，在胚龄18 d达到高峰[(29.45±3.34)%，P0.05]。Bcl-2和Bax蛋白表达也逐渐增加，均于胚龄18 d达到高峰，分别为（80.52±4.06、33.67±3.42

P0.05)。结论小鼠肾单位发育过程中各部位PCD的表现具有明显差异，出现了多种细胞凋亡形式，其中以经典凋亡为主，还出现了坏死性凋亡和副凋亡。

Abstract

Objective To observe ultrastructural changes of programmed cell death (PCD) during nephron development in mice. Methods Light microscopy

transmission electron microscopy

TUNEL method and immunohistochemical assay were used to observe programmed cell death of the nephrons in mouse kidney at embryonic days 12

and 18. Results There were 3 types of PCD found in the development of mouse nephron. They were apoptosis

necroptosis and paraptosis. TUNEL positive cells were increased gradually and reached peak level at embryonic day 18 [(29.45±3.34)%

P0.05]. The expression of Bcl-2 and Bax was increased

and peaked at embryonic day 18 too （80.52±4.06 and 33.67±3.42

P0.05). Conclusion There are obvious different changes of PCD among different regions during nephron development in mouse. In the cell death we observed

apoptosis is most common

and necroptosis and paraptosis are also seen.

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