Frequency of peripheral blood CD161<sup>+</sup>CD4<sup>+</sup> T cells in rheumatoid arthritis

周云涛; 刘静; 王志国; 郝丽宁; 刘畅; 周玉秀; 佟胜全; 田卫

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Frequency of peripheral blood CD161⁺CD4⁺ T cells in rheumatoid arthritis

更新时间：2026-01-09

- Frequency of peripheral blood CD161⁺CD4⁺ T cells in rheumatoid arthritis
- Journal of Army Medical University Vol. 34, Issue 5, Pages: 438-441(2012)
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  CLC： R593.22;R446.113;R392.1
- Published：2012
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周云涛,刘静,王志国,郝丽宁,刘畅,周玉秀,佟胜全,田卫.类风湿关节炎外周血CD4+CD161+T细胞亚群频数情况[J].陆军军医大学学报(原第三军医大学学报),2012,34(05):438-441.

　Zhou Yuntao,Liu Jing,Wang Zhiguo,Hao Lining,Liu Chang,Zhou Yuxiu,Tong Shengquan,Tian Wei.Frequency of peripheral blood CD161+CD4+ T cells in rheumatoid arthritis[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(05):438-441.
周云涛,刘静,王志国,郝丽宁,刘畅,周玉秀,佟胜全,田卫.类风湿关节炎外周血CD4+CD161+T细胞亚群频数情况[J].陆军军医大学学报(原第三军医大学学报),2012,34(05):438-441. DOI：

　Zhou Yuntao,Liu Jing,Wang Zhiguo,Hao Lining,Liu Chang,Zhou Yuxiu,Tong Shengquan,Tian Wei.Frequency of peripheral blood CD161+CD4+ T cells in rheumatoid arthritis[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(05):438-441. DOI：

摘要

目的检测外周血单个核细胞（peripheral blood mononuclear cells

PBMCs）中CD161

T细胞的频数变化，探讨其在类风湿关节炎（RA）发生、发展中的作用。方法收集唐山市工人医院风湿病科2009年6月至2010年6月21例类风湿关节炎患者，其中男性7例，女性14例，平均年龄55岁。采用PBMCs体外活化技术，应用流式细胞术检测RA患者外周血PBMCs中CD4

CD161

T细胞的频数情况。结果与年龄、性别匹配的健康人群相，RA患者PBMCs中CD161

CD4

T和CD161

Th1细胞的百分比显著降低[（27.53±7.34）% vs（22.75±5.11）%，（P0.05）；（11.35±4.36）% vs（8.21±3.93）%，（P0.05）

]

，导致RA患者CD161

与CD161

Th1细胞的比率下降，二者差异有显著性[（0.76±0.29）% vs（0.60±0.30）%，（P0.05）

]

。结论 RA患者滑膜炎性反应导致外周血CD161

CD4

T细胞及其Th1亚群与相应阴性T细胞群体的平衡紊乱，CD161

CD4

T细胞及其Th1亚群在RA的病理过程密切相关。

Abstract

Objective To investigate the frequency of CD161

T cells in peripheral blood mononuclear cells (PBMCs) from patients with rheumatoid arthritis (RA). Methods A total of 21 patients diagnosed as RA (14 women and 7 men

at an average age of 55) who hospitalized in our department from June 2009 to June 2010 were enrolled in this study. Another 21 age- and

sex-matched healthy volunteers served as normal control. PBMCs were obtained from RA patients and healthy subjects. CD161 positive T cells were identified by a four-color flow cytometer after ex vivo stimulation with phorbol myristate acetate and ionomycin in the present of brefeldin A (BFA). Results The frequencies of CD161

T cells and CD161

Th1 cells were significantly decreased within CD4

T cells of PBMCs from RA patients

respectively [(27.53±7.34)% vs (22.75±5.11)%

P0.05; (11.35±4.36)% vs (8.21±3.93)%

P0.05

]

which led to a decreased percentage of CD161

and CD161

Th1 cells in RA patients. Conclusion The inflammatory response of synovial membrane in RA patients results in the changes of CD161

CD4

T cells and CD161

Th1 cells

rather than those of the corresponding CD161

T cells

which suggests CD161

T cells might play an important role in the development of RA.

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Department of Traditional Chinese Medicine and Rheumatology and Immunology， First Affiliated Hospital， Army Medical University （Third Military Medical University）

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Department of Cardiac Surgery， First Affiliated Hospital， Army Medical University （Third Military Medical University）

Hospital Administration Office， First Affiliated Hospital， Army Medical University （Third Military Medical University）

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Frequency of peripheral blood CD161+CD4+ T cells in rheumatoid arthritis

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摘要

Abstract

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Keywords

references

Frequency of peripheral blood CD161⁺CD4⁺ T cells in rheumatoid arthritis