Objective       To investigate the suitable ablation temperature for renal sympathetic-nerve ablation for hypertension.       Methods       The canine model of hypertension was established by abdominal aortic constriction. Twenty healthy hybrid dogs

weighing 15 to 20 kg

were randomly divided into treatment group which underwent renal sympathetic-nerve ablation and control group (n=10). Ten dogs in treatment group were randomly divided into 45 ℃ and 50 ℃ groups (n=5) according to predetermined ablation temperature. Ablation was carried out in 1 month after modeling. Systolic blood pressure (SBP)

diastolic blood pressure (DBP) and mean arterial pressure (MAP) were measured before modeling as well as before ablation

1 and 2 months after ablation

respectively. Renal angiography was carried out in treatment group in 2 months after ablation. Renal artery vessels were examined pathologically with HE staining.        Results       At 1 month after modeling

blood pressure (BP) was increased significantly in both groups (P0.01). At 1 month after ablation

SBP was reduced significantly in treatment group (P0.05). At 2 months after ablation

SBP

DBP and MAP were markedly lower than those before ablation (P0.05

0.01) as well as those in control group (P0.05

0.01). No artery stenosis or other abnormality was observed in renal angiography review. Pathological results revealed that renal vascular injury was much more severe in 50 ℃ group than in 45 ℃ group.        Conclusion       45 ℃ can be used as a conventional ablation temperature for renal sympathetic-nerve ablation for hypertension.