Effects of the fibrinolytic on  two different anticoagulation protocols after transcatheter closure of atrial septal defects

王毅; 覃军; 黄岚; 宋耀明; 耿召华; 谭开彬; 林春梅

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Effects of the fibrinolytic on two different anticoagulation protocols after transcatheter closure of atrial septal defects

更新时间：2026-01-09

- Effects of the fibrinolytic on two different anticoagulation protocols after transcatheter closure of atrial septal defects
- Journal of Army Medical University Vol. 34, Issue 10, Pages: 980-982(2012)
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  CLC： R446.11;R654.2;R973.2
- Published：2012
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王毅,覃军,黄岚,宋耀明,耿召华,谭开彬,林春梅.两种抗凝方案下房间隔缺损封堵术后纤溶功能动态变化及意义[J].陆军军医大学学报(原第三军医大学学报),2012,34(10):980-982.

　Wang Yi,Qin Jun,Huang Lan,Song Yaoming,Geng Zhaohua,Tan Kaibing,Lin Chunmei.Effects of the fibrinolytic on two different anticoagulation protocols after transcatheter closure of atrial septal defects[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(10):980-982.
王毅,覃军,黄岚,宋耀明,耿召华,谭开彬,林春梅.两种抗凝方案下房间隔缺损封堵术后纤溶功能动态变化及意义[J].陆军军医大学学报(原第三军医大学学报),2012,34(10):980-982. DOI：

　Wang Yi,Qin Jun,Huang Lan,Song Yaoming,Geng Zhaohua,Tan Kaibing,Lin Chunmei.Effects of the fibrinolytic on two different anticoagulation protocols after transcatheter closure of atrial septal defects[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(10):980-982. DOI：

摘要

目的探讨两种抗凝方案下，房间隔缺损（atrial septal defect

ASD）封堵术后纤溶功能的变化规律及其意义。方法 85例成功进行封堵术治疗的ASD患者随机分为延长低分子肝素（prolong low molecular weight heparin

pLWMH）组及低分子肝素（LWMH）组，采用酶联免疫吸附法测定封堵术前、术后即刻、术后第1、2、3、7天及术后第1、3个月血浆组织型纤维溶酶原激活物(tissue plasminogen activator，tPA)、D-D二聚体(D-Dimer)水平。结果封堵术前pLWMH组和LWMH组tPA、D-Dimer无明显差异；术后即刻两组tPA、D-Dimer均较术前明显增加并均达峰值（P0.05）；术后第1、2天两组tPA、D-Dimer均逐渐下降，仍较术前增加；术后第3天两组tPA、D-Dimer均接近术前水平，pLWMH组高于LWMH组，差异无统计学意义。结论无论低分子肝素组还是延长低分子肝素组，ASD封堵术后纤溶功能一过性激活，至术后3 d恢复术前水平。

Abstract

Objective To investigate the effects of the fibrinolytil on the two different anticoagulation protocols after transcatheter closure of atrial septal defect (ASD) and the significance. Methods Eighty-five ASD patients who successfully underwent transcatheter closure of ASD were randomly divided into a low-molecular-weight heparin group (LMWH group) and a prolonged low-molecular-weight heparin group (pLMWH group). ELISA was applied for detecting the levels of tissue plasminogen activator (tPA) and D-Dimer at different time points including before the operation

immediately after the operation

and 1

30 and 90 d after the operation. Results Before the operation

the levels of tPA and D-D dimer showed no significant difference between the pLMWH group and the LMWH group. The levels of tPA and D-D dimer of the two groups immediately after the operation increased significantly as compared with those before the operation

and reached their peak levels (P0.05). The levels of tPA and D-D dimer declined slightly on 1 d and 2 d after operation (P0.05)

then decreased to be close to the baseline on 3 d

and returned to the baseline on 7

30 and 90 d. Conclusion The fibrinolytic system is transiently activated after transcatheter closure of ASD and returns to baseline on day 3 after operation in both the LMWH group and the pLMWH group.

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