Association between SNP in P53-binding site of Bax and risk of esophageal squamous cell carcinoma in southwest Chinese Han population

刘波涛; 王凯; 许雪青; 熊刚; 郭洪; 官兴颖; 白云

您当前的位置：

首页 >

文章列表页 >

Association between SNP in P53-binding site of Bax and risk of esophageal squamous cell carcinoma in southwest Chinese Han population

更新时间：2026-01-09

- Association between SNP in P53-binding site of Bax and risk of esophageal squamous cell carcinoma in southwest Chinese Han population
- Journal of Army Medical University Vol. 34, Issue 10, Pages: 963-966(2012)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R394.5;R730.23;R735.1
- Published：2012
- 稿件说明：
移动端阅览
刘波涛,王凯,许雪青,熊刚,郭洪,官兴颖,白云.Bax基因P53结合位点多态性与食管鳞癌易感性的关联研究[J].陆军军医大学学报(原第三军医大学学报),2012,34(10):963-966.

　Liu Botao,Wang Kai,Xu Xueqing,Xiong Gang,Guo Hong,Guan Xingying,Bai Yun.Association between SNP in P53-binding site of Bax and risk of esophageal squamous cell carcinoma in southwest Chinese Han population[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(10):963-966.
刘波涛,王凯,许雪青,熊刚,郭洪,官兴颖,白云.Bax基因P53结合位点多态性与食管鳞癌易感性的关联研究[J].陆军军医大学学报(原第三军医大学学报),2012,34(10):963-966. DOI：

　Liu Botao,Wang Kai,Xu Xueqing,Xiong Gang,Guo Hong,Guan Xingying,Bai Yun.Association between SNP in P53-binding site of Bax and risk of esophageal squamous cell carcinoma in southwest Chinese Han population[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(10):963-966. DOI：

摘要

目的探讨Bax基因P53结合位点多态性与我国西南地区食管鳞状细胞癌(esophageal squamous cell carcinoma，ESCC)发病的关联性。方法利用SNaPshot技术检测201例食管鳞癌病例组及183例健康对照的Bax基因rs1009316位点多态性的分布情况，分析不同基因型与食管鳞癌易感性的关联。结果食管鳞癌病例组和对照组中rs1009316 的CC和CT/TT基因型频率分别为 59.2%、40.8%和73.2%、26.8%，CT/TT相比CC增加食管鳞癌的发病风险(OR值为1.884，95%CI为1.224～2.901)，T等位基因增加食管鳞癌的发病风险（OR值1.620，95%CI为1.103～2.379）。分层分析发现，无吸烟史群体中，T等位基因(OR值为1.858，95%CI为1.050～3.288)及CT/TT基因型(OR值为2.178，95%CI为1.143～4.147)分别增加食管鳞癌的发病风险。结论在中国西南地区人群中，Bax基因P53结合区域的多态性位点rs1009316是食管鳞癌的危险因素之一。

Abstract

Objective To evaluate the association between single nucleotide polymorphism (SNP) in P53-binding site of Bax and the risk of esophageal squamous cell carcinoma (ESCC) in southwest Chinese Han population. Methods The SNaPshot technique was applied to detect genotype of rs1009316 in 201 cases of ESCC (ESCC group) and 183 cases of healthy controls (control group)

and the association between different genotypes of rs1009316 and the risk of ESCC was analyzed. Results The frequencies of the rs1009316 variants CC and CT/TT were 59.2% and 40.8% in the ESCC group and 73.2% and 26.8% in the control group

respectively. Compared with CC genotype

CT/TT genotype increased the risk of ESCC (OR 1.884

95% CI 1.224 to 2.901). T allele frequency was 20% in the ESCC group and 14% in the control group

and T allele was positively correlated with the risk of ESCC (OR 1.620

95% CI 1.103 to 2.379). In stratification analysis

CT/TT genotype and T allele increased the risk of ESCC in the subjects without smoking history. Conclusion rs1009316 a SNP lying in the p53-binding site of Bax

is a risk factor of ECSS in southwest Chinese Han population.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

PI3K/Akt signal pathway inhibits ischemia and hypoxia-induced myocardial apoptosis in rats

SRSF1 inhibits HBV replication by enhancing the stability of P53 in cell models

Construction of machine learning-based prognostic model of centrosome amplification-related genes for esophageal squamous cell carcinoma

Risk factors and treatment strategies of digestive tract foreign body perforation

Changes of pituitary hormones and related factors in patients with prolonged disorders of consciousness

Related Author

宋华培

黄跃生

党永明

张东霞

褚志刚

张琼

LIU Jiajun

LONG Shaoyuan

Related Institution

Key Laboratory of Molecular Biology for Infectious Diseases of Ministry of Education， Chongqing Medical University

First Affiliated Hospital， Air Force Medical University

Department of Gastroenterology， Second Affiliated Hospital， Army Medical University （Third Military Medical University）

⁰