Objective         To determine the correlation between interleukin 28B (IL-28B) polymorphism in chronic hepatitis C patients and their response to interferon treatment.       Methods         A total of 97 cases of identified chronic hepatitis C 1 type

including 63 cases of sustained virological response (SVR) and 34 cases of null virological response (NVR)

were collected from in-patient and out-patient of our department from 2009 to 2011. Their genomic DNA was extracted by molecular biology methods

and PCR directly sequencing was performed for SNPs genotyping of rs8099917 and rs12980275. The SNPs genotypes of the 2 sites were analyzed in the SVR and NVR group.        Results        Genotype of rs12980275 was only detected as AA

and AG

while that of rs8099917 was only TT and TG. There was no GG type found in both rs12980275 and rs8099917. Significant difference was found in the genotype distribution of rs12980275 and rs8099917 between the SVR group and NVR group (OR=3.288

95%CI=[1.171 to 9.234]

Pearson’s Chi square=5.416

P=0.020; OR=2.865; 95%CI= [1.006 to 8.154]

Pearson’s Chi square=4.081

P=0.043). The frequencies of alleles of rs12980275 were significant difference between the 2 groups (OR=2.846

95%CI=[1.086 to 7.464]

Pearson’s Chi square=4.828，P=0.028).The frequencies of alleles of rs8099917 had no significant difference between the 2 groups (OR=2.543

95%CI=[0.953 to 6.785]

Pearson’s Chi square=3.664，P=0.056). The genotypes distribution and the frequencies of alleles of  rs12980275 and rs8099917 had positive correlation between the 2 groups (Pearson’s r=0.236; Pearson’s r=0.205; Pearson’s r=0.158; Pearson’s r=0.137）.       Conclusion        Polymorphism of SNPs rs8099917 and rs12980275 are associated with outcomes of patients’ antiviral response to interferon. IL-28B genetic polymorphisms can provide a reliable basis for individual therapy and predicting treatment efficacy.