Objective To synthesize the analogues of salidroside. Methods Aglycons were synthesized with substituted benzaldehyde reduced by sodium borohydride as a starting material and reacted with acetobromo glucose
acetobromo galactose and acetobromo xylose
respectively
to produce acetyl glycoside which turned into glycoside after its acetyl was deprived. Results About 21 analogues of salidroside
including 3A
1
to 3G
1
3A
2
to 3G
2
and 3A
3
to 3G
3
were successfully synthesized. CA and Scifinder structure retrieval showed that the synthesized compounds were novel compounds except for 3A
1
3A
2
3B
1
3B
2
3F
1
and 3G
1
. Their structures were confirmed by MS and
1
H-NMR. Conclusion The synthetic method we used is suitable for the synthesis of salidroside analogues.