Objective       To investigate the oxidative damage of mouse liver induced by linear alkylbenzenesulfonate (LAS).       Methods        Forty healthy ICR mice were divided into 4 groups using the method of simple random sampling

that is

control

low-dosage group of LAS（150 mg/kg）

middle-dosage group of LAS （300 mg/kg） and high-dosage group of LAS（600 mg/kg） respectively

with every group including 5 male and 5 female mice. The test mice were administered by gavage for 60 d. The mice were weighed every 10 days and their behavior were observed. After 60 days

the mice were killed and liver index were calculated and pathological changes were examined. At the same time

the activity of superoxide dismutase (SOD)

glutathione peroxidase (GSH-Px)

lactate dehydrogenase (LDH) and nitric oxide synthas (NOS) and the content of malondialdehyde (MDA) were detected.       Results        LAS treatment at different doses for 60 d resulted a reduce in body weight gain

even in the change of decrease in body weight (compared with the control group

P0.05). Liver index of mice of the different dosage groups was increased [（6.25±0.38）%

（6.94±0.52）% and （7.42±0.44）% compared with the control group（5.32±0.58）%

P0.05]. Pathological examination indicated that the damages of liver were found in different degrees. Hydropsia

spotty necrosis and sinusoidal congestion was found in hepatic cells of high-dosage group. The content of MDA and the activity of LDH and NOS in hepatic tissue of LAS groups were increased remarkably

while the activity of SOD and GSH-Px was decreased obviously (compared with the control group P0.05

0.01).       Conclusion        LAS inhibits the body weight gain

injures hepatic tissue and influences oxidative ability in mice.