Alteration of white matter in patients with post-traumatic stress disorder: a study based on tract-based spatial statistics

张静娜; 邱明国; 谢兵; 陈翰; 张佳佳; 张钰; 张晔; 桑林琼; 王莉; 李敏; 王健

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Alteration of white matter in patients with post-traumatic stress disorder: a study based on tract-based spatial statistics

更新时间：2026-01-09

- Alteration of white matter in patients with post-traumatic stress disorder: a study based on tract-based spatial statistics
- Journal of Army Medical University Vol. 33, Issue 19, Pages: 2077-2080(2011)
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  CLC： R319;R322.81;R640.2
- Published：2011
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张静娜,邱明国,谢兵,陈翰,张佳佳,张钰,张晔,桑林琼,王莉,李敏,王健.基于纤维束骨架的空间统计方法研究创伤后应激障碍患者脑白质结构变化[J].陆军军医大学学报(原第三军医大学学报),2011,33(19):2077-2080.

　Zhang Jingna,Qiu Mingguo,Xie Bing,Chen Han,Zhang Jiajia,Zhang Yu,Zhang Ye,Sang Linqiong,Wang Li,Li min,Wang Jian.Alteration of white matter in patients with post-traumatic stress disorder: a study based on tract-based spatial statistics[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(19):2077-2080.
张静娜,邱明国,谢兵,陈翰,张佳佳,张钰,张晔,桑林琼,王莉,李敏,王健.基于纤维束骨架的空间统计方法研究创伤后应激障碍患者脑白质结构变化[J].陆军军医大学学报(原第三军医大学学报),2011,33(19):2077-2080. DOI：

　Zhang Jingna,Qiu Mingguo,Xie Bing,Chen Han,Zhang Jiajia,Zhang Yu,Zhang Ye,Sang Linqiong,Wang Li,Li min,Wang Jian.Alteration of white matter in patients with post-traumatic stress disorder: a study based on tract-based spatial statistics[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(19):2077-2080. DOI：

摘要

目的探讨创伤后应激障碍(post-traumatic stress disorder，PTSD)患者大脑白质纤维束的微观变化。方法对9例临床确诊PTSD患者和9例正常对照进行全脑弥散张量成像扫描，应用基于纤维束骨架的空间统计方法（tract-based spatial statistics

TBSS)对2组被试白质纤维束的部分各向异性(fractional anisotropy，FA) 值进行比较。结果 PTSD患者双侧的钩束、下额枕束、及右侧的额钳、丘脑前辐射、皮质脊髓束的FA值较对照组明显降低(P0.01)。结论 PTSD患者的相关脑区的脑白质FA值的显著下降

提示与记忆、情绪调节相关中枢的脑白质纤维髓鞘结构完整性发生退变或白质纤维数量减少。

Abstract

Objective To explore the changes of the white matter in patients with post-traumatic stress disorder (PTSD). Methods Diffusion-tensor imaging (DTI) was performed on 9 PTSD patients and 9 matched normal volunteers. Fractional anisotropy (FA) values of the white matter in PTSD patients were compared with those in volunteers by tract-based spatial statistics (TBSS). Results Compared with control participants

FA values were significantly decreased in the white matter of PTSD patients that include the bilateral uncinate fasciculus

the inferior fronto-occipital fasciculus

and the right frontal forceps

the anterior thalamic radiation

and the corticospinal tract(P0.01). Conclusion Significant decrease of FA values in the white matter of brain regions related to memory and emotion regulation in PTSD patients suggests degeneration or fewer fibers of these brain regions.

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