Clinical observation of breast cancer patients who underwent endoscopic surgery with carbon dioxide insufflation

于婵娟; 刘亚华; 努尔波拉提·加列力汗

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Clinical observation of breast cancer patients who underwent endoscopic surgery with carbon dioxide insufflation

更新时间：2026-01-09

- Clinical observation of breast cancer patients who underwent endoscopic surgery with carbon dioxide insufflation
- Journal of Army Medical University Vol. 33, Issue 23, Pages: 2520-2522(2011)
- 作者机构：
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- DOI：
  CLC： R614;R737.9;R654.7
- Published：2011
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于婵娟,刘亚华,努尔波拉提·加列力汗.乳腺癌患者保乳手术腔镜腋窝淋巴结清扫术中的病理生理变化[J].陆军军医大学学报(原第三军医大学学报),2011,33(23):2520-2522.

　Yu Chanjuan,Liu Yahua,Nuerbolati Jalielihan.Clinical observation of breast cancer patients who underwent endoscopic surgery with carbon dioxide insufflation[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(23):2520-2522.
于婵娟,刘亚华,努尔波拉提·加列力汗.乳腺癌患者保乳手术腔镜腋窝淋巴结清扫术中的病理生理变化[J].陆军军医大学学报(原第三军医大学学报),2011,33(23):2520-2522. DOI：

　Yu Chanjuan,Liu Yahua,Nuerbolati Jalielihan.Clinical observation of breast cancer patients who underwent endoscopic surgery with carbon dioxide insufflation[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(23):2520-2522. DOI：

摘要

目的探讨乳腺癌患者保乳手术腔镜腋窝淋巴结清扫术中机体相应的循环、呼吸、血气等病理生理变化。方法选择符合保乳条件的Ⅰ～Ⅱ期浸润性乳腺癌患者20例（维吾尔族），经患者要求择期行保乳手术开放切除病灶并进行乳腔镜下腋窝淋巴结清扫术，对比术时CO

充气前、充气后及放气后心率（HR）、脉搏血氧饱和度（SpO

）、平均动脉压（MAP）、气道峰压（Ppeak）、pH、动脉血氧分压[p（O

）

]

、动脉血二氧化碳分压[p（CO

）

]

及呼气末二氧化碳分压（PetCO

）等变化情况。结果 CO

充气后，HR和MAP迅速出现上升趋势，MAP在30～60 min变化达到最高峰，与充气前比较，差异有统计学意义（P0.05）。SpO

各时点比较差异无统计学意义（P0.05）。Ppeak与充气前比较，充气后逐渐升高，差异有统计学意义（P0.05）。呼吸参数PetCO

充气前与充气后各时点差异有统计学意义(P0.05)，放气后仍高于充气前(P0.05)。pH与充气前比较，充气中及放气后均降低（P0.05）。p（CO

）与充气前比较，充气中各时间均升高，放气后仍高于充气前，差异均有统计学意义（P0.05）。结论患者在CO

充气后均出现心率加快、血压升高，气道分压增高，PetCO

增高，p（CO

）升高，pH值降低等病理生理变化，术中需严密观察，及时对症处理。

Abstract

Objective To investigate the pathological and physiological changes of circulation

respiratory function and blood gas during endoscopic surgery in breast cancer with carbon dioxide (CO

) insufflation in the Uighur population. Methods Twenty Uygur patients who had breast cancer at Ⅰ-Ⅱ stages and underwent endo

scopic surgery were reviewed. Changes of heart rate (HR)

pulse oxygen saturation (SpO

)

mean arterial pressure (MAP)

peak airway pressure (Ppeak)

arterial partial pressure of oxygen [p(O

)

]

arterial partial pressure of carbon dioxide [p(CO

)

]

and pressure end-tidal CO

(PetCO

) at baseline

10 min

30 min

60 min after CO

insufflation and 15 min after CO

deflation were measured. Results HR and MAP increased rapidly after CO

insufflation. MAP reached peak level after 30-60 min insufflation

which was significantly different from that at the baseline (P0.05). There was no significant difference of SpO

at different time points of insufflation (P0.05). Compared with the baseline

Ppeak and PetCO

increased significantly after CO

insufflation (P0.05)

and PetCO

after CO

deflation was still higher than that at the baseline. The pH value decreased significantly after CO

insufflation and deflation compared with that at the baseline (P0.05). p(CO

) increased after CO

insufflation and was still higher after CO

deflation compared with that at the baseline (P0.05). Conclusion Breast cancer patients who underwent endoscopic surgery with CO

insufflation show an increase in HR

MAP

Ppeak

PetCO

p(CO

) and an decrease in pH. It is necessary to monitor blood gas level to ensure patients’ safety.

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