Association of polymorphism of human complement factor H gene rs1061170 with coronary heart disease in the Han population of Chongqing

周娟; 杨成明; 曾春雨; 陈鹏; 陈彩宇; 张小群

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Association of polymorphism of human complement factor H gene rs1061170 with coronary heart disease in the Han population of Chongqing

更新时间：2026-01-09

- Association of polymorphism of human complement factor H gene rs1061170 with coronary heart disease in the Han population of Chongqing
- Journal of Army Medical University Vol. 33, Issue 21, Pages: 2282-2285(2011)
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  CLC： R394-33;R394.3;R541.4
- Published：2011
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周娟,杨成明,曾春雨,陈鹏,陈彩宇,张小群.CFH基因rs1061170多态性与重庆汉族人群冠心病的关系研究[J].陆军军医大学学报(原第三军医大学学报),2011,33(21):2282-2285.

　Zhou Juan,Yang Chengming,Zeng Chunyu,Chen Peng,Chen Caiyu,Zhang Xiaoqun.Association of polymorphism of human complement factor H gene rs1061170 with coronary heart disease in the Han population of Chongqing[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(21):2282-2285.
周娟,杨成明,曾春雨,陈鹏,陈彩宇,张小群.CFH基因rs1061170多态性与重庆汉族人群冠心病的关系研究[J].陆军军医大学学报(原第三军医大学学报),2011,33(21):2282-2285. DOI：

　Zhou Juan,Yang Chengming,Zeng Chunyu,Chen Peng,Chen Caiyu,Zhang Xiaoqun.Association of polymorphism of human complement factor H gene rs1061170 with coronary heart disease in the Han population of Chongqing[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(21):2282-2285. DOI：

摘要

目的探讨CFH基因rs1061170单核苷酸多态性与冠心病的相关性。方法筛选2008年10月到2009年6月在我院心内科就诊的重庆汉族地区人群中243例，其中冠心病组175例和对照组68例，用荧光定量PCR分析法检测2组CFH基因rs1061170多态位点基因型，分析CFH基因的频率分布及比较不同基因型各亚组间临床代谢参数。结果冠心病组与对照组CFH基因rs1061107中TT、TC、CC基因型频率分别为87.4%、12.6%、0和94.1%、5.9%、0。两组基因型频率分布差异不显著（χ

=2.293，OR=2.301，95%CI为0.762-6.943，P0.05），冠心病组T等位基因频率为85.3%，对照组为97.05%，两组等位基因频率分布无统计学意义（χ

=2.164，OR=2.213，95%CI=0.748-6.546，P0.05）。冠心病组中TC基因人群的SBP、DBP、BUN、Cr明显高于TT基因人群（P0.05）。结论 CFH基因rs1061170多态性与重庆地区部分汉族人群冠心病的发生可能无相关性。

Abstract

Objective To study the correlation between single nucleotide polymorphism of human complement factor H gene (CFH) rs1061170 and coronary heart disease. Methods A total of 243 patients including 175 patients with coronary heart disease and 68 patients as controls who were admitted to the cardiology of Daping Hospital from Oct 2008 to Jun 2009 were enrolled. Fluorescence quantitative PCR was applied to detect the polymorphic genotype of CFH gene rs1061170 in the 243 patients. Frequency distribution of CFH gene was analyzed in CHD patients and control individuals. The clinical metabolic parameters of subgroups with different genotypes were compared. Results The frequency distributions TT

TC and CC genotypes of CFH gene rs1061107 in the CHD group and the control group were 87.4%

12.6% and 0 and 94.1%

5.9% and 0

respectively. The difference between the two groups was not significant (Chi square=2.293

OR=2.301

95%CI=0.762-6.943

P0.05). The frequency of T allele in the CHD group and the control group was 85.3% and 97.05%

respectively

and the difference was not significant (Chi square=2.164

OR=2.213

95%CI=0.748-6.546

P0.05). The SBP

DBP

BUN and Cr of CHD patients with TC genotype were significantly higher than those of the CHD patients with TT genotype (P0.05). Conclusion Polymorphism of CFH gene rs1061170 may not correlated with the incidence of coronary heart disease in the Han population of Chongqing.

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