A voxel-based morphometric MRI study in middle-aged female patients with first-episode major depressive disorders

刘海霞; 赵雯婧; 邓伟; 蒙华庆; 傅一笑; 杜莲; 邱海棠; 邱田; 邹志礼; 王婷; 雍那; 吴飞; 罗庆华

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A voxel-based morphometric MRI study in middle-aged female patients with first-episode major depressive disorders

更新时间：2026-01-09

- A voxel-based morphometric MRI study in middle-aged female patients with first-episode major depressive disorders
- Journal of Army Medical University Vol. 33, Issue 23, Pages: 2516-2519(2011)
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  CLC： R749.41;R445.2;R816.1
- Published：2011
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刘海霞,赵雯婧,邓伟,蒙华庆,傅一笑,杜莲,邱海棠,邱田,邹志礼,王婷,雍那,吴飞,罗庆华.中年女性首发重性抑郁症患者基于体素的形态学MRI研究[J].陆军军医大学学报(原第三军医大学学报),2011,33(23):2516-2519.

　Liu Haixia,Zhao Wenjing,Deng Wei,Meng Huaqing,Fu Yixiao,Du Lian,Qiu Haitang,Qiu Tian,Zou Zhili,Wang Ting,Yong Na,Wu Fei,Luo Qinghua.A voxel-based morphometric MRI study in middle-aged female patients with first-episode major depressive disorders[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(23):2516-2519.
刘海霞,赵雯婧,邓伟,蒙华庆,傅一笑,杜莲,邱海棠,邱田,邹志礼,王婷,雍那,吴飞,罗庆华.中年女性首发重性抑郁症患者基于体素的形态学MRI研究[J].陆军军医大学学报(原第三军医大学学报),2011,33(23):2516-2519. DOI：

　Liu Haixia,Zhao Wenjing,Deng Wei,Meng Huaqing,Fu Yixiao,Du Lian,Qiu Haitang,Qiu Tian,Zou Zhili,Wang Ting,Yong Na,Wu Fei,Luo Qinghua.A voxel-based morphometric MRI study in middle-aged female patients with first-episode major depressive disorders[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(23):2516-2519. DOI：

摘要

目的运用基于体素形态学(voxel-based morphometry，VBM)方法探索中年女性首发重性抑郁症患者与正常人脑结构差异。方法对15例未经治疗的中年女性首发重性抑郁症患者和30例正常对照者进行头颅MRI检查，通过3D扰相梯度回波序列(spoiled gradient recall，SPGR)获得3D T1图像，采用优化的VBM方法进行全脑比较分析。结果与正常对照组相比，抑郁症患者右侧枕中回灰质减少（P0.01，体素＞100），未发现灰质明显增加的区域（体素＜100）；左侧眶额回、右侧尾状核区白质减少（P0.01，体素＞100），未发现白质明显增加的区域（P0.01）。结论中年女性首发重性抑郁症患者的发病可能与枕中回、眶额回及尾状核区的脑结构改变有关。

Abstract

Objective To explore the differences of brain structures between middle-aged female patients with first-episode major depressive disorder (MDD) and healthy controls by optimized voxel-based morphometry (VBM). Methods Fifteen medication-naive middle-aged female patients with first-episode MDD and thirty healthy controls were examined by cranial MRI. Three-dimension (3D) T1 weighted MR images were obtained by 3D spoiled gradient recall (SPGR). The differences of the whole brain structure between the patients and the healthy controls were compared using optimized VBM. Results Compared with the healthy controls

the major depressive patients had significantly lower grey matter density (P0.01

voxel＞100) but without increase of grey matter (voxel＜100) in right middle occipital gyrus; and had significantly lower white matter density (P0.01

voxel＞100) without increase of white matter in left orbital frontal gyrus and right caudate nucleus (P0.01). Conclusion The mechanism of first-episode MDD in middle-aged female patients mayberelated to the brain structure changes in middle occipital gyrus

orbital frontal gyrus and caudate nucleus.

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