Objective      To investigate the risk factors of lung injury in neonatal infants delivered by women with  intrahepatic cholestasis of pregnancy（ICP）.       Methods      A total of 30 cases of ICP and their newborns were enrolled to ICP group

and  another 40 pairs of matched mothers and newborns underwent normal delivery were defined as control group. The incidence and clinical features of neonatal lung injury were analyzed. The relationship of bile acid and glycocholic acid in the serum and amino fluid with lung injury of newborns in the two groups was studied.       Results      The incidence of neonatal lung injury in ICP group was significantly higher than in control group（P0.01）. Transient tachypnea

neonatal pneumonia and neonate respiratory distress syndrome were the major types of lung injury. There was a good correlation between maternal bile acid and incidence of neonatal lung injury. The incidence of neonatal lung injury was elevated when serum glycocholic acid was over 40 μg/ml or serum bile acid over 30 μmol/L.       Conclusion      High level of bile acid in the maternal blood and amino fluid might be the cause of neonatal lung injury.