Objective      To explore the efficacy of repair treatment on rat erectile dysfunction induced by ischiocavernosus trauma.      Methods      One hundred and fifty male Wistar rats were randomly divided into a repair group Ⅰ(n=30)

a repair group Ⅱ (n=30)

a repair group Ⅲ(n=30)

a repair group Ⅳ (n=30)

a non-repair group (n=10)

a sham operation group (n=10) and a normal group (n=10). Both sides of rat ischiocavernosus were sewed up at different time of immediately

2 weeks

4 weeks and 8 weeks after the rat ischiocavernosus were severed in the four repair groups. The severed rat ischiocavernosus were not repaired in the non-repair group. The rat ischiocavernosus in the normal group were neither severed nor sewed up. A similar operation was performed in the sham operation group

but rat ischiocavernosus were not severed. After the repair operation

150 female Wistar rats at reproductive age but not pregnant were randomly selected to match those male rats one by one

and the male erection recovery were indirectly deduced based on the female pregnancy rate after 2-4 month observations.      Results      In repair groups Ⅰ-Ⅳ: the number of dead male rats was 3

6

5 and 0

respectively; the number of successfully matched female rats was 27

26

26 and 23

respectively; the number of pregnant female rats and the pregnancy rate were 17 (63.0%)

16 (61.5%)

15 (57.7%) and 14 (60.9%)

respectively. In the non-repair group: 1 male rat died

and 9 female rats were successfully matched with a 0% pregnancy rate. In the normal group and the sham operation group: no rats died and ten female rats were successfully matched with a 100% pregnancy rate. The comparisons of the female rats conception between each group showed that: the difference between the normal group and the sham operation group was not statistically significant (P0.05); both of the normal group and the sham operation group were statistically significant as compared with the non-repair group and the repair groups (P0.05); the non-repair group was statistically significant as compared with each repair group (P0.05); but the comparisons within the repair groups were not statistically significant.      Conclusion      The repair treatment of severed rat ischiocavernosus can improve rat erectile dysfunction

but the improvement is independent of the time.