hS100A6 inhibits proliferation, induces apoptosis and up-regulates Wnt/β-catenin activity in ovarian cancer cell lines HO8910 and HO8910 PM

邹正渝; 陈英华; 孙双双; 黎玉叶; 叶立伟; 段亮; 武睿; 杨霞; 罗进勇; 周兰

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hS100A6 inhibits proliferation, induces apoptosis and up-regulates Wnt/β-catenin activity in ovarian cancer cell lines HO8910 and HO8910 PM

更新时间：2026-01-09

- hS100A6 inhibits proliferation, induces apoptosis and up-regulates Wnt/β-catenin activity in ovarian cancer cell lines HO8910 and HO8910 PM
- Journal of Army Medical University Vol. 34, Issue 3, Pages: 214-218(2012)
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  CLC： R341;R730.23;R737.31
- Published：2012
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邹正渝,陈英华,孙双双,黎玉叶,叶立伟,段亮,武睿,杨霞,罗进勇,周兰.hS100A6抑制卵巢癌细胞HO8910和HO8910 PM增殖、促进凋亡并上调其Wnt/β-catenin 活性[J].陆军军医大学学报(原第三军医大学学报),2012,34(03):214-218.

　Zou Zhengyu,Chen Yinghua,Sun Shuangshuang,Li Yuye,Ye Liwei,Duan Liang,Wu Rui,Yang Xia,Luo Jinyong,Zhou Lan.hS100A6 inhibits proliferation, induces apoptosis and up-regulates Wnt/β-catenin activity in ovarian cancer cell lines HO8910 and HO8910 PM[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(03):214-218.
邹正渝,陈英华,孙双双,黎玉叶,叶立伟,段亮,武睿,杨霞,罗进勇,周兰.hS100A6抑制卵巢癌细胞HO8910和HO8910 PM增殖、促进凋亡并上调其Wnt/β-catenin 活性[J].陆军军医大学学报(原第三军医大学学报),2012,34(03):214-218. DOI：

　Zou Zhengyu,Chen Yinghua,Sun Shuangshuang,Li Yuye,Ye Liwei,Duan Liang,Wu Rui,Yang Xia,Luo Jinyong,Zhou Lan.hS100A6 inhibits proliferation, induces apoptosis and up-regulates Wnt/β-catenin activity in ovarian cancer cell lines HO8910 and HO8910 PM[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(03):214-218. DOI：

摘要

目的研究hS100A6（human S100A6）对人卵巢癌细胞系（低转移系HO8910和高转移系HO8910 PM）增殖、凋亡和Wnt/β-catenin信号途径的影响。方法通过MTT以及台盼蓝染色检测细胞增殖的变化；Hoechst检测细胞凋亡的变化；提取细胞总蛋白及核蛋白Western blot检测hS100A6对β-catenin的影响。结果 MTT及台盼蓝染色结果显示hS100A6抑制HO8910细胞和HO8910 PM细胞的增殖（P0.05），Hoechst染色结果显示hS100A6同时促进这两系细胞的凋亡（P0.05）；Western blot显示hS100A6增加β-catenin的水平并促进其发生核转位。结论 hS100A6能抑制人卵巢癌细胞系HO8910和HO8910 PM增殖，促进其凋亡，同时激活Wnt/β-catenin信号途径。

Abstract

Objective To investigate the effect of human S100A6 (hS100A6) on the proliferation

apoptosis and Wnt/β-catenin signaling pathway of ovarian cancer cell line HO8910 and HO8910 PM. Methods MTT assay and trypan blue exclusion assay

Hoechst staining and Western blotting were used to detect cell proliferation

apoptosis and expression and distribution of β-catenin

respectively. Results ① hS100A6 inhibited proliferation of HO8910 and HO8910 PM cells in a dose- and time-dependent manner (P0.05); ② hS100A6 induced apoptosis in HO8910 and HO8910 PM cells (P0.05); ③ Level of β-catenin was increased by hS100A6 in HO8910 and HO8910 PM cells

and β-catenin translocated from cytoplasm to nucleus. Conclusion hS100A6 can inhibit cell proliferation

induce cell apoptosis and up-regulate Wnt/β-catenin activity in ovarian cancer HO8910 and HO8910 PM cells.

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