Value of protein chip system-detected multi-tumor markers for diagnosis of colorectal cancer

龙驰; 胡义德; 曹正怀

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Value of protein chip system-detected multi-tumor markers for diagnosis of colorectal cancer

更新时间：2026-01-09

- Value of protein chip system-detected multi-tumor markers for diagnosis of colorectal cancer
- Journal of Army Medical University Vol. 34, Issue 1, Pages: 13-15(2012)
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  CLC： R446.112;R730.4;R735.35
- Published：2012
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龙驰,胡义德,曹正怀.血清多肿瘤标志物蛋白芯片检测结果在结直肠癌诊断中的价值[J].陆军军医大学学报(原第三军医大学学报),2012,34(01):13-15.

　Long Chi,Hu Yide,Cao Zhenghuai.Value of protein chip system-detected multi-tumor markers for diagnosis of colorectal cancer[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(01):13-15.
龙驰,胡义德,曹正怀.血清多肿瘤标志物蛋白芯片检测结果在结直肠癌诊断中的价值[J].陆军军医大学学报(原第三军医大学学报),2012,34(01):13-15. DOI：

　Long Chi,Hu Yide,Cao Zhenghuai.Value of protein chip system-detected multi-tumor markers for diagnosis of colorectal cancer[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(01):13-15. DOI：

摘要

目的探讨血清多肿瘤标志物蛋白芯片检测系统（C-12）检测结果对结直肠癌(CRC)的诊断价值。方法采用C-12对130例住院CRC患者（CRC组）和108例门诊体检人员（对照组）血清进行检测，分析C-12在两组人群之间、CRC不同TNM分期之间、C-12包含的12种肿瘤标志物之间、不同肿瘤标志物联合检测之间的阳性率差异。结果 CRC组C-12阳性率显著高于对照组（P0.01），随CRC分期升高而上升（P0.01），其中CEA、CA242、CA19-9阳性率显著高于其余9项肿瘤标志物（P0.01），CEA联合CA242、CA19-9检测能提高敏感度，但它们之间联合检测或12项肿瘤标志物联合检测与单项肿瘤标志物CEA相比差异无显著性（P0.05）。结论 C-12有助于CRC诊断，临床分期越晚诊断价值越高，其中CEA、CA242、CA19-9的诊断价值优于其余9项肿瘤标志物，多肿瘤标志物联合检测能提高检测敏感度，但并不显著优于单项肿瘤标志物CEA。

Abstract

Objective To study the value of protein chip system-detected multi-tumor markers for the diagnosis of colorectal cancer (CRC). Methods Serum tumor markers were detected with C-12 in 130 CRC patients (CRC group) and 108 normal adults (control group). TNM staging of CRC

C-12 containing 12 tumor markers and their positive rate between the two groups were analyzed. Results The positive rate of C-12 was significantly higher in CRC group than in control group and increased with the TNM staging (P0.01).The positive rates of CEA

CA242 and CA19-9 were significantly higher than those of the other 9 tumor markers (P0.01). Combined CEA and CA242 or CA19-9 increased the diagnosis rate of CRC. However

no significant difference was found in the diagnosis rate of CRC between combined CEA and 12 tumor markers or single CEA (P＞0.05). Conclusion C-12 contributes to the diagnosis of CRC. The later the TNM staging of CRC is

the higher the value of tumor markers is. The diagnosis value of CEA

CA242 and CA19-9 for the diagnosis of CRC is better than that of the other 9 tumor markers. Detection of multiple tumor markers is not advantageous to the detection of single CEA for the diagnosis of CRC.

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