Objective      To investigate the genetic effect of chromosome inversion on pregnancy outcome.       Methods      A total of 3 610 cases with history of abnormal pregnancy who were outpatients or consultants in our center were enrolled. Their peripheral blood samples were collected and cultured for G-band karyotyping. The results were studied with clinical data.       Results      There were 76 cases found with chromosome inversion in the 3 610 cases

including 14 different types of inversion. Among the 76 cases

46 individuals themselves or their spouses had history of miscarriage (12 cases with 1 miscarriage

24 cases with 2 miscarriages and 8 cases with 3 miscarriages). At the same time there were two cases of infertility

8 cases of stillbirth or abnormity

and 5 cases with abnormal sperm.       Conclusion      Chromosomal inversions may result in miscarriage

stillbirth and congenital malformation. Prenatal diagnosis to the carriers of inversion is of very important value.