IL-33 levels in peripheral blood plasma and sputum of patients with bronchial asthma and their correlation with symptoms of patients, pulmonary function, and eosinophil numbers

麻晓燕; 罗雅玲; 赖文岩; 邵金莲; 蓝海兵; 梁振宇

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IL-33 levels in peripheral blood plasma and sputum of patients with bronchial asthma and their correlation with symptoms of patients, pulmonary function, and eosinophil numbers

更新时间：2026-01-09

- IL-33 levels in peripheral blood plasma and sputum of patients with bronchial asthma and their correlation with symptoms of patients, pulmonary function, and eosinophil numbers
- Journal of Army Medical University Vol. 33, Issue 14, Pages: 1526-1529(2011)
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  CLC： R562.25;R446.62
- Published：2011
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麻晓燕,罗雅玲,赖文岩,邵金莲,蓝海兵,梁振宇.支气管哮喘患者外周血、痰液中IL-33的含量及其相关性分析[J].陆军军医大学学报(原第三军医大学学报),2011,33(14):1526-1529.

　Ma Xiaoyan,Luo Yaling,Lai Wenyan,Shao Jinlian,Lan Haibing,Liang Zhenyu.IL-33 levels in peripheral blood plasma and sputum of patients with bronchial asthma and their correlation with symptoms of patients, pulmonary function, and eosinophil numbers[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(14):1526-1529.
麻晓燕,罗雅玲,赖文岩,邵金莲,蓝海兵,梁振宇.支气管哮喘患者外周血、痰液中IL-33的含量及其相关性分析[J].陆军军医大学学报(原第三军医大学学报),2011,33(14):1526-1529. DOI：

　Ma Xiaoyan,Luo Yaling,Lai Wenyan,Shao Jinlian,Lan Haibing,Liang Zhenyu.IL-33 levels in peripheral blood plasma and sputum of patients with bronchial asthma and their correlation with symptoms of patients, pulmonary function, and eosinophil numbers[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(14):1526-1529. DOI：

摘要

目的检测支气管哮喘患者外周血和痰液中IL-33的含量，探讨其含量与患者症状、肺功能、血液和痰液中嗜酸性粒细胞数的关系。方法 ELISA法检测80例支气管哮喘患者及20例正常对照者外周血中IL-33的含量，对哮喘患者行24 h症状评分和肺功能测试，依据FEV

将支气管哮喘患者分为3组：FEV1≥80%为轻度哮喘组，60%≤FEV

＜80%为中度哮喘组，FEV

＜60%为重度哮喘组，并记录哮喘患者外周血中嗜酸性粒细胞数。ELISA法检测18例哮喘患者和8例正常对照者痰液中IL-33的含量，显微镜下计数其痰液中的嗜酸性粒细胞数。结果外周血IL-33水平在正常对照组和轻度哮喘组之间无明显差异[（26.62±3.04）pg/ml vs（30.26±5.23）pg/ml，P0.05

]

，但中、重度哮喘组的IL-33的水平要明显高正常对照组[（41.36±11.82）pg/ml vs（26.62±3.04）pg/ml，（84.10±20.17）pg/ml vs（26.62±3.04）pg/ml，P0.05

]

，且与患者夜间症状评分呈正相关（r=0.317，P0.05），而与白天症状评分和外周血嗜酸性粒细胞数无明显相关（r=0.173，P0.05，r=0.082，P0.05）

与患者FEV

和PEF均呈明显的负相关（r=-0.638，P0.05；r=-0.552，P0.05）。支气管哮喘患者诱导痰中IL-33的含量与痰液中嗜酸性粒细胞数目呈正相关(r=0.693，P0.05)。结论血液中的IL-33可作为一种评价哮喘患者肺功能下降程度的指标，是哮喘患者病情恶化的促进因子。 IL-33水平增高可能是诱导哮喘患者气道嗜酸性粒细胞浸润的原因之一。

Abstract

Objective To measure the IL-33 levels in the peripheral blood plasma and sputum of the patients with bronchial asthma

and to analyze their correlation with the symptoms of the patients

the pulmonary functio

n and the eosinophil numbers in the peripheral blood and sputum. Methods Eighty patients with bronchial patients and twenty normal control subjects were enrolled in the study. The IL-33 levels in the peripheral blood plasma of the patients and normal control subjects were measured by enzyme-linked immunosorbent assay (ELISA). The daytime and nighttime symptom scores of the patients were recorded

and the pulmonary function was tested. The patients were divided into a mild asthma group (FEV

≥80%)

a moderate asthma group (60%≤FEV

80%) and a severe asthma group (FEV

60%) according to their pulmonary function. The eosinophil numbers in the peripheral blood of the patients were recorded. Eighteen patients and eight normal control subjects were also subjected to ELISA to measure the IL-33 levels in the sputum. Their eosinophil numbers in the sputum were counted under a microscope. Results There was no significant difference of the IL-33 levels in the peripheral blood plasma between the control group and the mild asthma group (26.62±3.04 pg/ml vs 30.26±5.23 pg/ml

P0.05). The IL-33 levels in the peripheral blood plasma of the moderate and severe asthma groups were significantly higher than those in the control group (41.36±11.82 pg/ml vs 26.62±3.04 pg/ml

84.10±20.17 pg/ml vs 26.62±3.04 pg/ml

P0.05). The IL-33 levels in the peripheral blood plasma were positively correlated with the nighttime symptom scores (r=0.317

P0.05)

but not significantly correlated with the daytime symptom scores and the eosinophil numbers in the peripheral blood (r=0.173

P0.05; r=0.082

P0.05). The IL-33 levels in the peripheral blood plasma were significantly and negatively correlated with FEV

and expiratory peak flow (PEF) (r=-0.638

P0.05; r=-0.552

P0.05). The IL-33 levels in the sputum were positively correlated with the eosinophil numbers in sputum. Conclusion IL-33 in the peripheral blood plasma can be an indicator of the pulmonary function decline of the patients wit

h bronchial asthma

and is a promoting factor in the deterioration of asthma. The IL-33 level increase may be a cause of airway eosinophil infiltration.

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