Correlation between ultrasound-guided diffused optical tomography and expression of hypoxia inducible factor-1α in breast cancer

王红磊; 武力; 阙燕; 马大昌; 吴多明; 纪彩玉

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Correlation between ultrasound-guided diffused optical tomography and expression of hypoxia inducible factor-1α in breast cancer

更新时间：2026-01-09

- Correlation between ultrasound-guided diffused optical tomography and expression of hypoxia inducible factor-1α in breast cancer
- Journal of Army Medical University Vol. 33, Issue 11, Pages: 1187-1190(2011)
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  CLC： R737.9;R445.1;R730.4
- Published：2011
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王红磊,武力,阙燕,马大昌,吴多明,纪彩玉.超声光散射断层成像与乳腺癌HIF-1α表达的相关性[J].陆军军医大学学报(原第三军医大学学报),2011,33(11):1187-1190.

　Wang Honglei,Wu Li,Que Yan,Ma Dachang,Wu Duoming,Ji Caiyu.Correlation between ultrasound-guided diffused optical tomography and expression of hypoxia inducible factor-1α in breast cancer[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(11):1187-1190.
王红磊,武力,阙燕,马大昌,吴多明,纪彩玉.超声光散射断层成像与乳腺癌HIF-1α表达的相关性[J].陆军军医大学学报(原第三军医大学学报),2011,33(11):1187-1190. DOI：

　Wang Honglei,Wu Li,Que Yan,Ma Dachang,Wu Duoming,Ji Caiyu.Correlation between ultrasound-guided diffused optical tomography and expression of hypoxia inducible factor-1α in breast cancer[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(11):1187-1190. DOI：

摘要

目的通过研究术前乳腺癌超声光散射断层成像（diffused optical tomography with ultrasonography）的综合诊断指数（synthesis diagnostic index

SDI）以及术后缺氧诱导因子-1α(hypoxia inducible factor-1α

HIF-1α)、CD105在乳腺癌中的表达，探讨乳腺癌超声光散射断层成像综合诊断指数与缺氧诱导因子-1α表达、微血管密度（microvessel density

MVD）的关系。方法采用超声光散射断层成像系统

研究2008年11月至2010年9月我科131例乳腺良性肿块及142例乳腺癌患者，测量超声光散射断层成像综合诊断指数(synthesis diagnostic index

SDI)，通过受试者工作特征曲线（receiver operating characteristic curve

ROC曲线）确定乳腺癌的最佳诊断阈值。使用免疫组化法检测HIF-1α表达与定位，检测乳腺癌MVD。分析超声光散射SDI值与HIF-1α表达、MVD值的关系。分析超声光散射的SDI值以及HIF-1α表达与乳腺癌临床病理特征的关系。结果乳腺良性疾病与乳腺癌的SDI值分别：(109.35±48.03)、(190.87±60.33)。两者之间的差异有统计学意义（P0.05）。经ROC曲线分析确定，以SDI值＞141.2作为乳腺癌的最佳诊断阈值。HIF-1α表达阳性的乳腺癌SDI值高于HIF-1α表达阴性的乳腺癌（P0.05）。SDI值与MVD值呈正相关（r=0.673

P0.01）。HIF-1α表达阳性的MVD值大于HIF-1α表达阴性的MVD值（P0.05）。SDI值、HIF-1α表达与乳腺癌临床病理联系显示：两者与肿瘤大小、淋巴结转移、TNM分期、CerbB-2表达有关（P0.05）与ER、PR表达无关（P0.05）。 结论 超声光散射断层成像系统作为一种新的功能性检测技术对乳腺癌的诊断、病情判断方面有重要的指导意义。

Abstract

Objective To study the correlation between synthesis diagnostic indications (SDI) of ultrasound-guided diffused optical tomography (DOT)

expression of hypoxia inducible factor-1α (HIF-1α)

and microvessel density (MVD) in breast cancer. Methods SDI were demonstrated by ultrasound-guided DOT for 131 patients with benign mass and 142 patients with breast cancer admitted to our department from November 2008 to September 2010. Optimal diagnostic threshold of breast cancer was established by receiver operating characteristic (ROC) curve. Expressions of HIF-1α and MVD in breast cancer were detected with the immunohistochemical method. Correlation of SDI with expression of HIF-1α and MVD in breast cancer

and pathological features of breast cancer was analyzed. Results The SDI value was significantly lower in patients with benign breast mass than in those with breast cancer (109.35±48.03 vs 190.87±60.33

P0.05). ROC curve analysis showed that the SDI value greater than 141.2 was used as the optimal diagnostic threshold of breast cancer. The SDI and MVD values were significantly higher in breast cancer with positive HIF-1α expression than in that with negative HIF-1α expression (P0.05). The SDI value was positively correlated with the MVD value (r=0.673

P0.01). The SDI value and the expression of HIF-1α were significantly correlated with the tumor size

lymphatic metastasis

TNM stage

and CerbB-2 expression (P0.05)

but not with the ER and PR expression. Conclusion As a new function testing technique

ultrasound-guided DOT plays an important role in diagnosis of breast cancer.

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