Objective      To establish a new animal model of hyperglycemia associated with form-deprivation myopia/amblyopia in order to provide animal experiment data for researching the relationship between early stage diabetic retinopathy and refraction error.     Methods      A total of 30 one-week-old BALB/cJ mice were randomly divided into 3 groups (n=10 for each group)

control group (group Ⅰ)

hyperglycemia group [group Ⅱ

repeatedly injected of 50 mg/kg streptozotoein (STZ) intraperitoneally from 30 d after birth to induce hyperglycemia]

and hyperglycemia and form-deprivation myopia/amblyopia group (group Ⅲ

with their right eyes were sutured at 10 d after birth

and then injected with 50 mg/kg STZ in 30 d after birth). Their blood glucose level were measured from 1 d after STZ injection

once a week. Their dioptres were examined

and body weight and ocular axial length were measured in 82 to 87 d.     Results      Group Ⅱ and group Ⅲ had much higher blood glucose (20.66±3.51 and 21.05±5.91 mmol/L) and significantly lower body weight (18.02±3.90 and 15.87±5.61 g) when compared with those of control group (8.77±4.38 mmol/L and 26.90±4.38 g respectively

P0.01). Compared with group Ⅰ (11.80±2.24 D

3.310±0.041 mm) and group Ⅱ (12.25±1.77 D and 3.315±0.031 mm)

the diopter was significantly decreased and the ocular axial length was elongated obviously in the right eyes of group Ⅲ (3.348±0.018 mm

9.05±1.42 D

P0.01).     Conclusion      Hyperglycemia associated with form-deprivation myopia can be induced in BALB/cJ mice successfully through STZ injection and eye lid suturing when the mice are within 10-day-old.