Objective    To observe the clinical effects of nitrous oxide inhalation conscious sedation on extraction of impacted teeth.     Methods    Forty patients

whose mandibular third molars needed extraction

were randomly divided into an experimental group (n=20) and a control group (n=20). The patients in the experimental group were subjected to extraction of impacted teeth under nitrous oxide inhalation conscious sedation and local anesthesia

while the patients in the control group were subjected to extraction of impacted teeth under routine local anesthesia. The duration of tooth extraction and the changes of systolic blood pressure (SBP)

diastolic blood pressu

re (DBP)

heart rate (HR)

and pulse oxygen saturation (SpO

2

) were recorded. The pain levels and sedation effects were analyzed with visual analogue scale (VAS) and Ramsay scale.     Results    The duration of tooth extraction in the experimental group was significantly shorter than that of the control group (19.90±2.11 min vs 22.85±2.54 min

P0.05). SBP

DBP

HR

and SpO

2

changed more smoothly in the experimental group than in the control group. The local anesthesia and intraoperative VAS scores in the experimental group were significantly lower than those in the control group (1.10±0.72 and 1.75±0.64 vs 2.35±0.87 and 3.25±0.55

P0.05)

indicating reduced pain levels. The preoperative and intraoperative Ramsay scores in the experimental group were significantly higher than those in the control group (2.55±0.51 and 2.35±0.48 vs 1.55±0.51 and 1.35±0.49

P0.05)

indicating increased sedation effects.     Conclusion    Nitrous oxide inhalation conscious sedation is safe and effective in extraction of impacted teeth.