Prognosis and efficacy of new adjuvant combination endocrine therapy versus radical surgery for prostate cancer： a meta-analysis study

王家武; 姜庆; 樊晓栋

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Prognosis and efficacy of new adjuvant combination endocrine therapy versus radical surgery for prostate cancer： a meta-analysis study

更新时间：2026-01-09

- Prognosis and efficacy of new adjuvant combination endocrine therapy versus radical surgery for prostate cancer： a meta-analysis study
- Journal of Army Medical University Vol. 33, Issue 13, Pages: 1388-1391(2011)
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  CLC： R737.25;R730.5;R181.23
- Published：2011
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王家武,姜庆,樊晓栋.新辅助内分泌联合治疗与单纯根治性手术对前列腺癌预后和疗效的Meta分析[J].陆军军医大学学报(原第三军医大学学报),2011,33(13):1388-1391.

　Wang Jiawu,Jiang Qing,Fan Xiaodong.Prognosis and efficacy of new adjuvant combination endocrine therapy versus radical surgery for prostate cancer： a meta-analysis study[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(13):1388-1391.
王家武,姜庆,樊晓栋.新辅助内分泌联合治疗与单纯根治性手术对前列腺癌预后和疗效的Meta分析[J].陆军军医大学学报(原第三军医大学学报),2011,33(13):1388-1391. DOI：

　Wang Jiawu,Jiang Qing,Fan Xiaodong.Prognosis and efficacy of new adjuvant combination endocrine therapy versus radical surgery for prostate cancer： a meta-analysis study[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(13):1388-1391. DOI：

摘要

目的系统评价新辅助内分泌治疗局限性前列腺癌的有效性。方法计算机检索Cochrane图书馆、PubMed、EMBASE、中国生物医学文献数据库、中国期刊全文数据库、中文科技期刊数据库和万方数据库。检索时间为1993-2010年。并追查已纳入文献的参考文献。收集有关新辅助内分泌治疗与单纯根治性手术治疗前列腺癌的随机对照研究，并按Cochrane协作网推荐的方法进行系统评价。结果共纳入18项研究，4 267例患者。Meta分析结果显示：新辅助内分泌治疗对精囊浸润率无显著改善，但可以改善前列腺癌无生化复发生存率(RR 1.41

95%CI=1.12～1.78

P=0.003)，显著降低手术切缘阳性率(RR 0.48

95%CI=0.43～0.53

P0.05)、淋巴结转移率(RR 0.64

95%CI=0.44～0.93

P=0.02)。结论新辅助内分泌治疗可以显著降低手术切缘阳性率、淋巴结转移率及前列腺癌无生化复发生存率，但对精囊浸润率无改善。

Abstract

Objective To assess the efficacy of neo-adjuvant hormone therapy (NHT) in localized advanced prostate cancer. Methods We searched Cochrane Library

PubMed

EMBASE

Chinese Biomedical Literature Database

Chinese Journal Full-text Database (Chinese National Knowledge Infrastructure

CNKI)

China Scientific Journal Database (CSJD

VIP database) and Wanfang Database for randomized trials comparing NHT plus radical prostatectomy with radical prostatectomy alone published during 1993 to 2010. Data were extracted and evaluated by two reviewers independently with a designed extraction form recommended by Cochrane

The references in the extracted literature were also retrieved. The RevMan 5.0 software was used for data analysis. Results Eighteen randomized trials involving 4 267 patients were included. The results of meta-analyses indicated that NHT prior to prostatectomy did not improve positive seminal vesicles rates

but did significantly improve disease-free survival (RR=1.41

95% CI 1.12 to 1.78

P=0.003)

and significantly reduced positive margin rates (RR=0.48

95% CI 0.43 to 0.53

P0.00001)

lymph node invasion (RR=0.64

95% CI 0.44 to 0.93

P=0.02). Conclusion NHT plus radical prostatectomy significantly reduces positive margin rates and lymph node invasion and improves disease-free survival rates

but has no effect on positive seminal vesicles rates.

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