Oxidative stress up-zegnlale IL-17 in patients with Graves’ ophthalmopathy

李强; 田杰; 陈紫君; 李霞绯; 刘纯

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Oxidative stress up-zegnlale IL-17 in patients with Graves’ ophthalmopathy

更新时间：2026-01-09

- Oxidative stress up-zegnlale IL-17 in patients with Graves’ ophthalmopathy
- Journal of Army Medical University Vol. 33, Issue 10, Pages: 1068-1070(2011)
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  CLC： R581.102;R392.3;R363.13
- Published：2011
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李强,田杰,陈紫君,李霞绯,刘纯.氧化应激上调IL-17水平在Graves眼病中的意义[J].陆军军医大学学报(原第三军医大学学报),2011,33(10):1068-1070.

　Li Qiang,Tian Jie,Chen Zijun,Li Xiafei,Liu Chun.Oxidative stress up-zegnlale IL-17 in patients with Graves’ ophthalmopathy[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(10):1068-1070.
李强,田杰,陈紫君,李霞绯,刘纯.氧化应激上调IL-17水平在Graves眼病中的意义[J].陆军军医大学学报(原第三军医大学学报),2011,33(10):1068-1070. DOI：

　Li Qiang,Tian Jie,Chen Zijun,Li Xiafei,Liu Chun.Oxidative stress up-zegnlale IL-17 in patients with Graves’ ophthalmopathy[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(10):1068-1070. DOI：

摘要

目的研究氧化应激及细胞因子白细胞介素17（IL-17）在Graves眼病（Graves ophthalmopathy，GO）发病中的作用。方法收集15例正常对照组和25例初发Graves眼病病例组外周血，检测血清中丙二醛(MDA)、超氧化物歧化酶(SOD)以及IL-17水平。从正常对照和病例组中各选取10例，采外周血分离T淋巴细胞，每例标本均分为空白对照组（H

=0，VitC=0）、过氧化氢组（H

=1 000 nmol/L，VitC=0）、维生素C组（H

=0，VitC=25 μmol/L）、过氧化氢+维生素C组（H

=1 000 nmol/L，VitC=25 μmol/L）。体外培养后检测细胞培养上清液IL-17水平并进行统计分析。 结果 ①GO病例组血清MDA、IL-17明显高于正常对照组（P0.05），SOD水平及SOD/MDA显著低于正常对照组（P0.05），且IL-17与MDA呈显著正相关(r=0.527，P0.01)；②T淋巴细胞培养上清液IL-17水平检测分析，GO病例组中H

组显著高于空白对照组、VitC组及H

+VitC组（P0.05）；VitC组及H

+VitC组均明显低于空白对照组（P0.05）。正常对照者各组间无显著差异（P0.05）。结论氧化应激可诱导GO患者T淋巴细胞分泌IL-17，抗氧化剂VitC可在一定程度减少IL-17释放。

Abstract

Objective To investigate the relationship between oxidative stress and secretion of interleukin-17 (IL-17) from T cells

and to study the effect of IL-17 on pathogenesis of Graves’ ophthalmopathy (GO). Methods Venous blood from 15 healthy persons and 25 patients newly diagnosed with GO was collected to prepare serum s

pecimens

and the levels of malondialdehyde (MDA)

superoxide dismutase (SOD)

and IL-17 in the serum specimens were analyzed. Venous blood from 10 of the healthy persons and 10 of the GO patients was additionally collected to prepare T-cell specimens. Each of the T-cell specimens was divided into a blank group [H

vitamin C (VitC)=0

]

an H

treatment group (H

=1 μmol/L

VitC=0)

a VitC treatment group (H

VitC=25 μmol/L)

and an H

+VitC treatment group (H

=1 μmol/L

VitC=25 μmol/L). The T-cell specimens were cultured in vitro

and the IL-17 level of each group was tested. Results The levels of MDA and IL-17 in the serum specimens from the GO patients were significantly higher than those in the serum specimens from the healthy persons (6.77±1.11 nmol/mL and 13.62±2.43 ng/L vs 4.16±0.61 nmol/ml and 10.15±0.93 ng/L

P0.05). The SOD level and SOD/MDA ratio of the serum specimens from the GO patients were significantly lower than those of the serum specimens from the healthy persons (53.95±17.53 U/ml and 7.9±3.5 vs 73.16±15.33 U/ml and 18.1±5.2

P0.05). The IL-17 level and MDA level of the serum specimens from the GO patients were in significantly positive correlation (r=0.527

P0.01). In the GO patients

the IL-17 level of the H

treatment group was significantly higher than those of the blank group

VitC treatment group

and H

+VitC treatment group (27.55±4.75 ng/L vs 20.24±2.13 ng/L

18.76±1.13 ng/L

and 17.59±1.85 ng/L

P0.05)

and the IL-17 levels of the VitC treatment group and H

+VitC treatment group were significantly lower than that of the blank group (18.76±1.13 and 17.59±1.85 vs 20.24±2.13

P0.05). No significant differences were found in IL-17 levels of the groups from healthy persons (P0.05). Conclusion Oxidative stress can induce IL-17 secretion from T cells of patients wi

th Graves’ ophthalmopathy. Antioxidant VitC can inhibit the secretion to a certain degree.

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