High expression of monocyte chemotactic protein-1 in malignant bone tumor

胡旭; 初同伟; 廖通权; 余世明; 刘玉刚; 周跃

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High expression of monocyte chemotactic protein-1 in malignant bone tumor

更新时间：2026-01-09

- High expression of monocyte chemotactic protein-1 in malignant bone tumor
- Journal of Army Medical University Vol. 33, Issue 9, Pages: 924-927(2011)
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  CLC： R738.1;R341;R730.2
- Published：2011
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胡旭,初同伟,廖通权,余世明,刘玉刚,周跃.单核细胞趋化蛋白-1在恶性骨肿瘤中高表达[J].陆军军医大学学报(原第三军医大学学报),2011,33(09):924-927.

　Hu Xu,Chu Tongwei,Liao Tongquan,Yu Shiming,Liu Yugang,Zhou Yue.High expression of monocyte chemotactic protein-1 in malignant bone tumor[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(09):924-927.
胡旭,初同伟,廖通权,余世明,刘玉刚,周跃.单核细胞趋化蛋白-1在恶性骨肿瘤中高表达[J].陆军军医大学学报(原第三军医大学学报),2011,33(09):924-927. DOI：

　Hu Xu,Chu Tongwei,Liao Tongquan,Yu Shiming,Liu Yugang,Zhou Yue.High expression of monocyte chemotactic protein-1 in malignant bone tumor[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(09):924-927. DOI：

摘要

目的探讨单核细胞趋化蛋白-1(monocyte chemotactic protein-1

MCP-1）在人转移性骨肿瘤、恶性原发性骨肿瘤、良性骨肿瘤组织中差异性表达及其意义。方法 2008年12月至2010年9月期间，收集转移性骨肿瘤15例、原发性恶性骨肿瘤15例、良性骨肿瘤15例，总共45例骨肿瘤标本。半定量RT-PCR检测各组MCP-1 mRNA的表达水平。应用免疫组织化学S-P法检测MCP-1蛋白的表达水平、Image-Pro Plus（IPP）分析标本中阳性细胞的累积光密度值和阳性表达面积。结果转移性骨肿瘤组MCP-1 mRNA相对表达量（0.862±0.042）高于恶性原发组（0.612±0.051）和良性组（0.171±0.021）（P0.05）。转移性骨肿瘤组织中MCP-1免疫组化累积光密度（4 532.12±190.02）和阳性面积[（513.32±89.08） μm

]

均高于原发性恶性骨肿瘤组[（2 592.11±120.21）、（308.34±79.33） μm

]

和良性骨肿瘤组[（551.22±79.12）、（115.91±32.68） μm

]

，且其在原发恶性组中的表达水平也高于良性组（P0.05）。结论 MCP-1在恶性骨肿瘤中高表达，在转移性骨肿瘤表达更显著。

Abstract

Objective To identify the expression of monocyte chemotactic protein-1 (MCP-1) in human metastatic bone tumors

primary malignant bone tumors and benign bone tumor tissues

and the correlation between its expression and pathologic features of metastatic bone tumor. Methods A total of 15 tissue samples of metastatic bone tumor

15 samples of primary malignant bone tumor and 15 samples of benign bone tumor were collected. The mRNA and protein expression of MCP-1 were detected with RT

-PCR and immunohistochemistry

respectively. Image-Pro Plus image analyzer was used to analyze the integrated optical density and positive expression area. Results The mRNA level of MCP-1 was higher in metastatic bone tumor than in primary malignant bone tumor and benign bone tumor (0.862±0.042 vs 0.612±0.051 and 0.171±0.021

P0.05). The positive expression of MCP-1 protein was strongly higher in metastatic bone tumor than in primary malignant bone tumor and benign bone tumor tumor (integrated optical density: 4 532.12±190.02 vs 2 592.11±120.21 and 551.22±79.12

positive area: 513.32±89.08 vs 308.34±79.33 and 115.91±32.68 μm

P0.05). Conclusion MCP-1 is highly expressed in malignant bone tumors and more strongly in metastatic bone tumors.

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